Murase M
Laboratory of Information Research, Tokyo Metropolitan Institute of Gerontology, Japan.
J Theor Biol. 1990 Sep 21;146(2):209-31. doi: 10.1016/s0022-5193(05)80136-5.
Murase et al. (1989, J. theor. Biol. 139, 413) showed that an excitable dynein model can generate flagellar-like bending waves of low amplitude along an axoneme suspended in a viscous fluid. Either regular base-to-tip and irregular tip-to-base propagating waves can be produced. The present study shows that if the force-vs.-distance functions (or the potential energy functions as their integral form) that represent the functional properties of dyneins differ in the basal region, as compared with the rest of the active length of a short axoneme, and also differ between the opposing doublets, ciliary-like repetitive beats can be simulated. Depending on the parameter values, a cilium beats once and then becomes resting or quiescent, at the end of either its recovery or effective stroke. Interestingly, a quiescent cilium exhibits repetitive beats when a steady flow of water is applied to a part of the cilium in a suitable direction and at an appropriate speed. This kind of responsiveness to external stimuli, called directional mechano-sensitivity, may account for metachronal waves over a layer of cilia. As in the previous model for flagellar movement, the present model requires a passive region at the tip, but does not need a curvature feedback control, to generate ciliary-like beating patterns.
村濑等人（1989年，《理论生物学杂志》139卷，413页）表明，一个可激发的动力蛋白模型能够沿着悬浮在粘性流体中的轴丝产生低振幅的鞭毛状弯曲波。既可以产生从基部到顶端的规则传播波，也可以产生从顶端到基部的不规则传播波。本研究表明，如果代表动力蛋白功能特性的力与距离函数（或作为其积分形式的势能函数）在基部区域与短轴丝活性长度的其余部分相比有所不同，并且在相对的双联体之间也有所不同，那么就可以模拟出纤毛状的重复搏动。根据参数值的不同，纤毛在其恢复冲程或有效冲程结束时，搏动一次后就会进入静止或不活动状态。有趣的是，当以合适的方向和适当的速度向纤毛的一部分施加稳定水流时，静止的纤毛会表现出重复搏动。这种对外部刺激的反应，称为定向机械敏感性，可能解释了一层纤毛上的同步波。与之前的鞭毛运动模型一样，本模型在顶端需要一个被动区域，但不需要曲率反馈控制来产生纤毛状的搏动模式。
