Ozenırler Seren, Erkan Gülbanu, Gülbahar Ozlem, Bostankolu Ozge, Ozbaş Demırel Ozlem, Bılgıhan Ayşe, Akyol Gülen
Departments of, Gastroenterology, Gazi University School of Medicine, Ankara.
Turk J Gastroenterol. 2011 Feb;22(1):47-53. doi: 10.4318/tjg.2011.0156.
BACKGROUND/AIMS: Oxidative stress increases in chronic hepatitis C, and antioxidant defense mechanisms are impaired. The aims of this study were to compare chronic hepatitis C patients and healthy subjects according to oxidative stress and antioxidant system markers, and to determine the relationship between oxidative stress and hepatosteatosis.
This is an observational study in a tertiary center. Twenty-nine biopsy-proven chronic hepatitis C patients, with no prior anti-viral treatment and persistently elevated serum transaminase levels for 6 months, were included. The control group included 46 healthy subjects. Advanced oxidation protein products and malonyldialdehyde levels were measured. Total radical-trapping antioxidant parameter was calculated.
Baseline characteristics were similar in the patient and control groups. In chronic hepatitis C patients, serum levels of advanced oxidation protein products were significantly higher than in the control group (235.0±142.8 vs 116.7±79.5, p<0.001). Serum levels of malonyldialdehyde were also significantly higher than in the control group (9.3±2.1 vs 6.5±1.1, p<0.001). However, there was no significant difference in total radical-trapping antioxidant parameter. The total radical-trapping antioxidant parameter/advanced oxidation protein products index was significantly lower in chronic hepatitis C patients than in healthy controls (p<0.05). There was no significant correlation between advanced oxidation protein products and malonyldialdehyde and hepatosteatosis.
We conclude that oxidative stress occurs in chronic hepatitis C, and antioxidant defense mechanisms are inadequate. Serum levels of advanced oxidation protein products and malonyldialdehyde are higher in chronic hepatitis C patients when compared to healthy individuals, and may be useful markers in chronic hepatitis C.
背景/目的：慢性丙型肝炎中氧化应激增加，抗氧化防御机制受损。本研究的目的是根据氧化应激和抗氧化系统标志物比较慢性丙型肝炎患者和健康受试者，并确定氧化应激与肝脂肪变性之间的关系。
这是一项在三级中心进行的观察性研究。纳入了29例经活检证实的慢性丙型肝炎患者，这些患者未曾接受过抗病毒治疗，血清转氨酶水平持续升高6个月。对照组包括46名健康受试者。测量了晚期氧化蛋白产物和丙二醛水平。计算了总自由基捕获抗氧化参数。
患者组和对照组的基线特征相似。在慢性丙型肝炎患者中，晚期氧化蛋白产物的血清水平显著高于对照组（235.0±142.8 vs 116.7±79.5，p<0.001）。丙二醛的血清水平也显著高于对照组（9.3±2.1 vs 6.5±1.1，p<0.001）。然而，总自由基捕获抗氧化参数没有显著差异。慢性丙型肝炎患者的总自由基捕获抗氧化参数/晚期氧化蛋白产物指数显著低于健康对照组（p<0.05）。晚期氧化蛋白产物和丙二醛与肝脂肪变性之间没有显著相关性。
我们得出结论，慢性丙型肝炎中存在氧化应激，抗氧化防御机制不足。与健康个体相比，慢性丙型肝炎患者的晚期氧化蛋白产物和丙二醛血清水平更高，可能是慢性丙型肝炎的有用标志物。
