Leiden University Medical Center, Dutch Working Party Infection Prevention, C7-130, Postbus 9600, 2300 RC Leiden, Germany.
Crit Care. 2011;15(2):R111. doi: 10.1186/cc10135. Epub 2011 Apr 11.
A semi-upright position in ventilated patients is recommended to prevent ventilator-associated pneumonia (VAP) and is one of the components in the Ventilator Bundle of the Institute for Health Care Improvement. This recommendation, however, is not an evidence-based one.
A systematic review on the benefits and disadvantages of semi-upright position in ventilated patients was done according to PRISMA guidelines. Then a European expert panel developed a recommendation based on the results of the systematic review and considerations beyond the scientific evidence in a three-round electronic Delphi procedure.
Three trials (337 patients) were included in the review. The results showed that it was uncertain whether a 45° bed head elevation was effective or harmful with regard to the occurrence of clinically suspected VAP, microbiologically confirmed VAP, decubitus and mortality, and that it was unknown whether 45° elevation for 24 hours a day increased the risk for thromboembolism or hemodynamic instability. A group of 22 experts recommended elevating the head of the bed of mechanically ventilated patients to a 20 to 45° position and preferably to a ≥ 30° position as long as it does not pose risks or conflicts with other nursing tasks, medical interventions or patients' wishes.
Although the review failed to prove clinical benefits of bed head elevation, experts prefer this position in ventilated patients. They made clear that the position of a ventilated patient in bed depended on many determinants. Therefore, given the scientific uncertainty about the benefits and harms of a semi-upright position, this position could only be recommended as the preferred position with the necessary restrictions.
建议对接受通气治疗的患者采取半卧位以预防呼吸机相关性肺炎(VAP),这也是改善医疗保健协会通气捆绑治疗中的一个组成部分。然而,这一推荐并无充分的证据支持。
我们根据 PRISMA 指南对接受通气治疗的患者采取半卧位的利弊进行了系统评价。随后,一个欧洲专家小组根据系统评价的结果以及科学证据之外的因素,在三轮电子德尔菲法程序中制定了一项推荐意见。
纳入的 3 项试验共纳入 337 例患者。结果显示,床头抬高 45°在预防临床疑似 VAP、微生物确诊 VAP、压疮和死亡率方面的有效性或有害性尚不确定,也不确定 24 小时床头抬高 45°是否会增加血栓栓塞或血流动力学不稳定的风险。一组 22 名专家建议将机械通气患者床头抬高至 20°至 45°,最好抬高至≥30°,只要这不会给其他护理任务、医疗干预或患者意愿带来风险或冲突。
尽管该系统评价未能证明床头抬高的临床获益,但专家更倾向于对通气患者采取该体位。他们明确表示,通气患者的卧床体位取决于许多决定因素。因此,鉴于半卧位的获益和危害存在科学不确定性,仅能将该体位推荐为首选体位,并应附加必要的限制条件。