Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Fertil Steril. 2011 Jun;95(7):2200-3. doi: 10.1016/j.fertnstert.2011.03.044. Epub 2011 Apr 9.
The National Institute of Child Health and Human Development has conducted a series of vision workshops to set an ambitious but tenable broad agenda, transcending traditional organizational and disciplinary boundaries. This presentation sets forth a vision regarding how the aspects of a woman's reproductive lifespan are interrelated, likely starting from childhood all the way to the later reproductive years. As a woman propagates, this circular interaction is then transmitted to the next generation. We need an understanding of the clinical processes, the time course, the natural history, and disruptors of these processes. With that understanding, we can then bring tools to bear to assess these issues, whether these tools are epidemiology, demography, social science, molecular biology, proteomics, genomics, or epigenomics. Our future research agenda should investigate how reproduction affects health and how health affects reproduction.
美国国家儿童健康与人类发展研究所举办了一系列视觉研讨会，制定了一个雄心勃勃但可行的广泛议程，超越了传统的组织和学科界限。本演讲阐述了一个愿景，即女性生殖寿命的各个方面是如何相互关联的，可能从儿童期一直延续到生殖后期。随着女性的繁衍，这种循环互动会传递给下一代。我们需要了解这些过程的临床过程、时间进程、自然史和干扰因素。有了这种理解，我们就可以利用工具来评估这些问题，无论这些工具是流行病学、人口学、社会科学、分子生物学、蛋白质组学、基因组学还是表观基因组学。我们未来的研究议程应该研究生殖如何影响健康，以及健康如何影响生殖。
