Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Republic of Korea.
Diabetes Res Clin Pract. 2011 Jul;93(1):70-6. doi: 10.1016/j.diabres.2011.03.018. Epub 2011 Apr 11.
We investigated the effect of Ishige okamurae extract on blood glucose level and insulin resistance in C57BL/-KsJ-db/db mice. We administered a standard AIN-93G diet with or without IOE to the animals for 6 weeks. After 6 weeks, blood glucose level was improved and blood glycosylated hemoglobin levels were lowered in sample group mice as compared to those in the diabetic control group mice. Hyperinsulinemia was reduced in the I. okamurae extract group mice with type 2 diabetes. With regard to hepatic glucose metabolic enzyme activities, glucokinase activity was enhanced in the IOE group mice, while glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities in the IOE group mice were significantly lowered than those in the diabetic control group mice. In addition, the hepatic glycogen content was elevated in the IOE group as compared to that in the diabetic control group. The homeostatic index of insulin resistance was lower in the I. okamurae extract group mice than in the diabetic control group mice. These results suggest that a dietary supplement of I. okamurae extract lowers the blood glucose level by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance.
我们研究了石花菜提取物对 C57BL/-KsJ-db/db 小鼠血糖水平和胰岛素抵抗的影响。我们将标准 AIN-93G 饮食与 IOE 一起或不与 IOE 一起给动物喂食 6 周。6 周后，与糖尿病对照组相比，样本组小鼠的血糖水平得到改善，血糖糖化血红蛋白水平降低。2 型糖尿病小鼠的石花菜提取物组胰岛素血症降低。关于肝葡萄糖代谢酶活性，IOE 组小鼠的葡萄糖激酶活性增强，而 IOE 组小鼠的葡萄糖-6-磷酸酶和磷酸烯醇丙酮酸羧激酶活性明显低于糖尿病对照组小鼠。此外，IOE 组小鼠的肝糖原含量高于糖尿病对照组。石花菜提取物组小鼠的胰岛素抵抗稳态指数低于糖尿病对照组。这些结果表明，石花菜提取物的膳食补充剂通过改变肝葡萄糖代谢酶活性降低血糖水平，并改善胰岛素抵抗。
