Department of Pediatric Neurology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Pediatr Neurol. 2011 May;44(5):385-8. doi: 10.1016/j.pediatrneurol.2010.11.020.
Epilepsia partialis continua is defined as a spontaneous regular or irregular clonic muscular twitching affecting a limited part of the body, occurring for a minimum of 1 hour and recurring at intervals of less than 10 seconds. Levamisole is used as an immunomodulating medication in patients with recurrent aphthous ulcers. Evidence suggests that it can induce multifocal inflammatory leukoencephalopathy. We describe the clinical neuroimaging and ictal electroencephalographic findings in an adolescent with epilepsia partialis continua caused by the administration of levamisole with cortical and subcortical lesions. To our knowledge, this is the first report that describes the association of epilepsia partialis continua cortical lesions detected by magnetic resonance imaging and levamisole that were not previously described.
部分连续性癫痫发作定义为自发性有规律或无规律的影响身体有限部位的阵挛性肌肉抽搐，持续至少 1 小时，且每 10 秒内反复发作。左旋咪唑被用作复发性口腔溃疡患者的免疫调节药物。有证据表明，它可引起多灶性炎症性白质脑病。我们描述了一名青少年的临床神经影像学和发作期脑电图发现，该患者因使用左旋咪唑导致皮质和皮质下病变而出现部分连续性癫痫发作。据我们所知，这是首次报道描述磁共振成像检测到的与之前未描述的左旋咪唑相关的部分连续性癫痫发作皮质病变。
