Instituto Cajal, CSIC, Ave. Doctor Arce 37, Madrid 28002, Spain.
Epilepsy Res. 2011 Dec;97(3):308-17. doi: 10.1016/j.eplepsyres.2011.02.009. Epub 2011 Apr 9.
A major goal in epilepsy research is to understand the cellular basis of pathological forms of network oscillations, particularly those classified as high-frequency activity. What are the underlying mechanisms, and how do they arise? The topic of this review is the pattern of high-frequency oscillations that have been recorded in epileptic tissue, and how they might differ from physiological activity. We discuss recent experimental and clinical data with a major focus on the diverse sources of extracellular signals and the contribution of different neuronal populations, including GABAergic interneurons and glutamatergic principal cells.
癫痫研究的一个主要目标是理解病理性网络振荡的细胞基础，特别是那些被归类为高频活动的形式。其潜在机制是什么，它们又是如何产生的？本篇综述的主题是在癫痫组织中记录到的高频振荡模式，以及它们可能与生理活动的不同之处。我们讨论了最近的实验和临床数据，主要集中在不同的细胞外信号源以及不同神经元群体（包括 GABA 能中间神经元和谷氨酸能主神经元）的贡献。
