CD5 淋巴细胞受体在健康和疾病中的免疫调节特性。
The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease.
机构信息
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Circuito Escolar s/n, Aptdo Postal 70228, Ciudad Universitaria, México, DF 04510, Mexico.
出版信息
Curr Opin Immunol. 2011 Jun;23(3):310-8. doi: 10.1016/j.coi.2011.03.003. Epub 2011 Apr 7.
Abstract
CD5 is a scavenger-like receptor expressed in association with the antigen-specific receptors on T and B-1a lymphocytes. Recent studies reveal a broader biology for CD5 that includes its role as regulator of cell death and as a receptor for pathogen-associated molecular patterns, in addition to its previously described function as an inhibitory receptor. These findings shed new light into the mechanistic role of CD5 in leukemias and effector cells to exogenous (infectious) or endogenous (autoimmune, tumoral) antigens. The newly identified properties make this receptor a potential candidate to be targeted for therapeutic intervention as well as immune modulation. This review describes the current knowledge on the function of CD5 as an immunomodulatory receptor both in health and in disease.
摘要
CD5 是一种清道夫样受体，与 T 和 B-1a 淋巴细胞上的抗原特异性受体表达相关。最近的研究揭示了 CD5 的更广泛的生物学功能，除了其先前描述的作为抑制性受体的功能外，它还作为细胞死亡的调节剂和病原体相关分子模式的受体。这些发现为 CD5 在白血病和效应细胞中外源（感染性）或内源（自身免疫、肿瘤）抗原中的机制作用提供了新的认识。新发现的特性使该受体成为治疗干预和免疫调节的潜在候选靶点。这篇综述描述了 CD5 作为免疫调节受体在健康和疾病中的功能的现有知识。
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