Laroumagne S, Salinas-Pineda A, Hermant C, Murris M, Gourraud P-A, Do C, Segonds C, Didier A, Mazières J
Service de pneumologie, clinique des voies respiratoires, hôpital Larrey, CHU de Toulouse, 24 chemin de Pouvourville, Toulouse cedex 09, France.
Rev Mal Respir. 2011 Mar;28(3):328-35. doi: 10.1016/j.rmr.2010.05.020. Epub 2011 Feb 3.
Bronchial colonisation is frequently reported in patients with lung cancer. These colonisations could influence patient therapeutic management and prognosis. The aim of our study is refine incidence and nature of bronchial colonisations in patients presenting with lung cancer.
Three hundred and eighty-eight patients with lung cancer underwent a flexible bronchoscopy at the time of diagnosis. Among them, 216 patients had a bacteriological, mycobacteriological and fungal investigation. Type and frequency of these colonisations were analyzed.
Potential pathogens were found in 39.8% of samples, including mainly 39.8% of Gram-negative bacilli (Haemophilus influenzae, Enterobacter sp., Escherichia coli). In addition, we found 0.9% of mycobacteria and 13.9% of Candida albicans. Among these 216 patients where microbiological analysis was performed, patient features and tumor stage were not significantly correlated to microbial colonisation.
Colonisation of airways is frequently reported when a lung cancer is diagnosed. Our data suggest that bronchial colonisation should be prospectively collected due to its potential interest in the management of lung cancer patients.
肺癌患者中支气管定植的情况屡有报道。这些定植可能会影响患者的治疗管理和预后。我们研究的目的是明确肺癌患者支气管定植的发生率及性质。
388例肺癌患者在确诊时接受了纤维支气管镜检查。其中，216例患者进行了细菌学、分枝杆菌学和真菌学检查。对这些定植的类型和频率进行了分析。
在39.8%的样本中发现了潜在病原体，主要包括39.8%的革兰氏阴性杆菌（流感嗜血杆菌、肠杆菌属、大肠杆菌）。此外，我们发现了0.9%的分枝杆菌和13.9%的白色念珠菌。在这216例进行微生物分析的患者中，患者特征和肿瘤分期与微生物定植无显著相关性。
肺癌确诊时气道定植情况屡有报道。我们的数据表明，鉴于支气管定植对肺癌患者管理可能具有的意义，应前瞻性地收集相关数据。
