Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Taiwan J Obstet Gynecol. 2011 Mar;50(1):37-41. doi: 10.1016/j.tjog.2009.11.003.
To investigate the relationship between Helicobacter pylori infection and hyperemesis gravidarum (HG) during early pregnancy by using serologic and stool antigen tests in developing South Anatolia region of Turkey.
A prospective cross-sectional study was performed on 40 pregnant women with HG and 40 asymptomatic controls without gastric problems at 7-12 weeks of gestation. The sociodemographic characteristics were recorded. The presence of H pylori was analyzed in the sera of the study-group patients by serology-specific IgG test in serum and by a stool antigen test in fecal samples.
The rates of serology-specific H pylori IgG positivity were 80% (32 of 40) in patients with HG and 35% (14 of 40) in control group. The difference between the two groups was significant [odds ratio: 6.9 (confidence interval: 2.2-22.1); p<0.01]. The rates of H pylori stool antigen test positivity were 87.5% (35 of 40) in patients with HG and 62.5% (25 of 40) in control groups. The difference between the two groups was significant (odds ratio: 4.5, confidence interval: 1.09-18.5); p=0.028.
Both serology-specific IgG and stool antigen tests seem to be good screening methods to identify H pylori in our pregnant patient population with HG during early pregnancy.
通过血清学和粪便抗原检测，在土耳其南部安纳托利亚地区研究早期妊娠时幽门螺杆菌（H.pylori）感染与妊娠剧吐（HG）的关系。
对 40 例妊娠剧吐和 40 例无胃部问题的无症状对照孕妇（妊娠 7-12 周）进行前瞻性横断面研究。记录社会人口统计学特征。通过血清特异性 IgG 试验和粪便抗原试验分析研究组患者血清中 H. pylori 的存在情况。
HG 组患者血清学特异性 H. pylori IgG 阳性率为 80%（32/40），对照组为 35%（14/40）。两组差异有统计学意义[比值比：6.9（95%置信区间：2.2-22.1）；p<0.01]。HG 组 H. pylori 粪便抗原检测阳性率为 87.5%（35/40），对照组为 62.5%（25/40）。两组差异有统计学意义（比值比：4.5，95%置信区间：1.09-18.5；p=0.028）。
在本研究的妊娠剧吐孕妇中，血清学特异性 IgG 和粪便抗原检测似乎都是早期妊娠 H. pylori 检测的良好筛查方法。
