Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China.
Biomaterials. 2011 Jul;32(21):4725-36. doi: 10.1016/j.biomaterials.2011.03.046. Epub 2011 Apr 11.
Biodegradable polymers can serve as barriers to prevent the post-operative intestinal adhesion. Herein, we synthesized a biodegradable triblock copolymer poly(ɛ-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ɛ-caprolactone-co-lactide) (PCLA-PEG-PCLA). The concentrated polymeric aqueous solution was injectable, and a hydrogel could be rapidly formed due to percolation of a self-assembled micelle network at the body temperature without requirement of any chemical reactions. This physical hydrogel retained its integrity in vivo for a bit more than 6 weeks and was eventually degraded due to hydrolysis. The synthesized polymer exhibited little cytotoxicity and hemolysis; the acute inflammatory response after implanting the hydrogel was acceptable, and the degradation products were less acidic than those of other polyester-containing materials. A rabbit model of sidewall defect-bowel abrasion was employed, and a significant reduction of post-operative peritoneal adhesion has been found in the group of in situ formed PCLA-PEG-PCLA hydrogels.
可生物降解聚合物可用作防止术后肠粘连的屏障。在此，我们合成了一种可生物降解的三嵌段共聚物聚（ε-己内酯-共-丙交酯）-b-聚乙二醇-b-聚（ε-己内酯-共-丙交酯）（PCLA-PEG-PCLA）。在体温下，由于自组装胶束网络的渗透，浓度较高的聚合物水溶液可迅速形成水凝胶，而无需任何化学反应。这种物理水凝胶在体内保持完整状态超过 6 周，最终由于水解而降解。合成的聚合物表现出低细胞毒性和低溶血作用；水凝胶植入后的急性炎症反应是可接受的，且降解产物的酸性低于其他含聚酯材料。我们采用了侧壁缺损-肠粘连的兔模型，结果发现原位形成的 PCLA-PEG-PCLA 水凝胶可显著减少术后腹膜粘连。
