State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 19 Xinjiekou Wai St, Beijing 100875, People's Republic of China.
Pediatrics. 2011 May;127(5):e1280-7. doi: 10.1542/peds.2010-2833. Epub 2011 Apr 11.
Amplitude-integrated electroencephalogram (aEEG) is a valuable tool for the continuous evaluation of functional brain maturation in infants. The amplitudes of the upper and lower margins of aEEGs are postulated to change with maturation and correlate with postmenstrual age (PMA). In this study we aimed to establish reliable reference values of aEEG amplitudes, which provide quantitative guidelines for assessing brain maturation as indicated by aEEG results in neonates and young infants.
aEEGs from healthy infants (n = 274) with PMAs that ranged from 30 to 55 weeks were divided into 10 groups according to their PMAs. Two 5-minute segments were selected from each aEEG and were used to automatically calculate the upper and lower margins and bandwidths of the aEEG tracings.
Interobserver agreement was achieved with an overall correlation of 0.99. The upper and lower margins of the aEEGs in both active and quiet sleep clearly rose in infants after the neonatal period. The bandwidth defined as the graphic distance decreased almost monotonically throughout the PMA range from 30 to 55 weeks. The lower margin of the aEEG was positively correlated with PMA, with a larger rank correlation coefficient during quiet sleep (r = 0.89) than during active sleep (r = 0.49).
Reference values of aEEG amplitudes were obtained for infants with a wide range of PMAs and constituted the basis for the quantitative assessment of aEEG changes with maturation in neonates and young infants. The normative amplitudes of aEEG margins, especially of the lower margin in quiet sleep, are recommended as a source of reference data for the identification of potentially abnormal aEEG results.
振幅整合脑电图（aEEG）是评估婴儿大脑功能成熟度的一种有价值的工具。aEEG 的上下边缘幅度据推测会随着成熟而变化，并与胎龄（PMA）相关。本研究旨在建立 aEEG 幅度的可靠参考值，为评估新生儿和小婴儿的 aEEG 结果所指示的脑成熟提供定量指南。
将胎龄为 30 至 55 周的健康婴儿（n=274）的 aEEG 分为 10 组，根据胎龄分组。从每个 aEEG 中选择 2 个 5 分钟的片段，用于自动计算 aEEG 描记的上下边缘和带宽。
观察者间的一致性达到了 0.99 的总体相关性。在新生儿期后，活跃睡眠和安静睡眠中的 aEEG 上下边缘在婴儿中明显升高。带宽定义为图形距离，在从 30 周到 55 周的 PMA 范围内几乎单调下降。aEEG 的下边缘与 PMA 呈正相关，安静睡眠时的秩相关系数较大（r=0.89），而活跃睡眠时的秩相关系数较小（r=0.49）。
获得了具有广泛 PMA 的婴儿的 aEEG 幅度参考值，为定量评估新生儿和小婴儿的 aEEG 随成熟的变化奠定了基础。建议将 aEEG 边缘的正常幅度，特别是安静睡眠时的下边缘，作为识别潜在异常 aEEG 结果的参考数据来源。
