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对核因子κB的药理学抑制可延长黑腹果蝇的寿命。

Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster.

作者信息

Moskalev Alexey, Shaposhnikov Mikhail

机构信息

Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia.

出版信息

Aging (Albany NY). 2011 Apr;3(4):391-4. doi: 10.18632/aging.100314.

DOI:10.18632/aging.100314
PMID:21483034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3117454/
Abstract

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

摘要

衰老与核因子κB依赖性促炎反应有关。在此我们证明，用吡咯烷二硫代氨基甲酸盐抑制核因子κB可分别延长黑腹果蝇雌性和雄性的平均寿命（13%-20%）以及90%死亡率时的年龄（11%-14%）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd5/3117454/2a5496ea37a7/aging-03-391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd5/3117454/72b147b28563/aging-03-391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd5/3117454/2a5496ea37a7/aging-03-391-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd5/3117454/72b147b28563/aging-03-391-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd5/3117454/2a5496ea37a7/aging-03-391-g002.jpg

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