Sirt1在骨骼肌中的生理作用。
The physiological roles of Sirt1 in skeletal muscle.
作者信息
Pardo Patricia S, Boriek Aladin M
机构信息
Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Baylor College of Medicine, One Baylor Plaza 825E, Houston TX 77030, USA.
出版信息
Aging (Albany NY). 2011 Apr;3(4):430-7. doi: 10.18632/aging.100312.
Abstract
Skeletal muscle aging is associated with increased inflammation and oxidative stress, a decrease in the ability to rebuild muscle after injury and in response to exercise. In this perspective, we discuss the mechanisms regulating Sirt1 activity and expression in skeletal muscles, emphasizing their implications in muscle physiology and the impairment of muscle function with age.
摘要
骨骼肌衰老与炎症增加和氧化应激有关，损伤后及运动后肌肉重建能力下降。从这个角度出发，我们讨论了调节骨骼肌中Sirt1活性和表达的机制，强调了它们在肌肉生理学中的意义以及随着年龄增长肌肉功能的受损情况。
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