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本文引用的文献

1
Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration.与衰老和年龄相关性黄斑变性相关的 RPE 中线粒体 DNA 损伤与修复。
Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3521-9. doi: 10.1167/iovs.10-6163.
2
mTOR: from growth signal integration to cancer, diabetes and ageing.mTOR：从生长信号整合到癌症、糖尿病和衰老。
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35. doi: 10.1038/nrm3025. Epub 2010 Dec 15.
3
mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.mTOR 介导的视网膜色素上皮细胞去分化引发小鼠光感受器变性。
J Clin Invest. 2011 Jan;121(1):369-83. doi: 10.1172/JCI44303. Epub 2010 Dec 6.
4
Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration.线粒体 DNA 损伤作为与年龄相关的黄斑变性的潜在机制。
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5470-9. doi: 10.1167/iovs.10-5429. Epub 2010 May 26.
5
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
6
Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells.β-淀粉样蛋白（1-42）改变视网膜色素上皮细胞的结构和功能。
Aging Cell. 2009 Apr;8(2):162-77. doi: 10.1111/j.1474-9726.2009.00456.x. Epub 2009 Feb 23.
7
Mitochondrial DNA damage and its potential role in retinal degeneration.线粒体DNA损伤及其在视网膜变性中的潜在作用。
Prog Retin Eye Res. 2008 Nov;27(6):596-607. doi: 10.1016/j.preteyeres.2008.09.001. Epub 2008 Sep 23.
8
The genomic response of the retinal pigment epithelium to light damage and retinal detachment.视网膜色素上皮细胞对光损伤和视网膜脱离的基因组反应。
J Neurosci. 2008 Sep 24;28(39):9880-9. doi: 10.1523/JNEUROSCI.2401-08.2008.
9
SOD2 knockdown mouse model of early AMD.早期年龄相关性黄斑变性的超氧化物歧化酶2基因敲低小鼠模型。
Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4407-20. doi: 10.1167/iovs.07-0432.
10
Current concepts in the pathogenesis of age-related macular degeneration.年龄相关性黄斑变性发病机制的当前概念
Arch Ophthalmol. 2004 Apr;122(4):598-614. doi: 10.1001/archopht.122.4.598.

mTOR pathway activation in age-related retinal disease.

作者信息

Zhao Chen, Vollrath Douglas

机构信息

Nanjing Medical University, First Affiliated Hospital, Nanjing, 210029, China.

出版信息

Aging (Albany NY). 2011 Apr;3(4):346-7. doi: 10.18632/aging.100303.

DOI:10.18632/aging.100303
PMID:21483039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3117448/
Abstract
摘要