mTOR pathway activation in age-related retinal disease.
作者信息
Zhao Chen, Vollrath Douglas
机构信息
Nanjing Medical University, First Affiliated Hospital, Nanjing, 210029, China.
出版信息
Aging (Albany NY). 2011 Apr;3(4):346-7. doi: 10.18632/aging.100303.
Abstract
摘要
相似文献
1
mTOR pathway activation in age-related retinal disease.mTOR通路在年龄相关性视网膜疾病中的激活
Aging (Albany NY). 2011 Apr;3(4):346-7. doi: 10.18632/aging.100303.
2
mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.mTOR 介导的视网膜色素上皮细胞去分化引发小鼠光感受器变性。
J Clin Invest. 2011 Jan;121(1):369-83. doi: 10.1172/JCI44303. Epub 2010 Dec 6.
3
Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration.异常早期内体生物发生在黄斑变性模型的视网膜色素上皮中介导补体激活。
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9014-9019. doi: 10.1073/pnas.1805039115. Epub 2018 Aug 20.
4
MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway.微小RNA-184通过靶向AKT2/哺乳动物雷帕霉素靶蛋白信号通路促进视网膜色素上皮细胞的分化。
Oncotarget. 2016 Aug 9;7(32):52340-52353. doi: 10.18632/oncotarget.10566.
5
Erythropoietin protects retinal pigment epithelial cells from oxidative damage.促红细胞生成素可保护视网膜色素上皮细胞免受氧化损伤。
Free Radic Biol Med. 2009 Apr 15;46(8):1032-41. doi: 10.1016/j.freeradbiomed.2008.11.027. Epub 2008 Dec 24.
6
Circular Noncoding RNA NR3C1 Acts as a miR-382-5p Sponge to Protect RPE Functions via Regulating PTEN/AKT/mTOR Signaling Pathway.环状非编码 RNA NR3C1 通过调控 PTEN/AKT/mTOR 信号通路作为 miR-382-5p 的海绵体来保护 RPE 功能。
Mol Ther. 2020 Mar 4;28(3):929-945. doi: 10.1016/j.ymthe.2020.01.010. Epub 2020 Jan 15.
7
The aging of the retina.视网膜的老化。
Exp Gerontol. 2003 Aug;38(8):825-31. doi: 10.1016/s0531-5565(03)00093-7.
8
Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling.丹酚酸 A 通过激活 Nrf2/HO-1 信号通路保护 RPE 细胞免受氧化应激。
Free Radic Biol Med. 2014 Apr;69:219-28. doi: 10.1016/j.freeradbiomed.2014.01.025. Epub 2014 Jan 28.
9
Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats.雷帕霉素防治大鼠年龄相关性黄斑变性样视网膜病变。
Am J Pathol. 2012 Aug;181(2):472-7. doi: 10.1016/j.ajpath.2012.04.018. Epub 2012 Jun 7.
10
Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress.自噬和角蛋白8可保护视网膜色素上皮细胞在氧化应激下免于退化。
Autophagy. 2017 Feb;13(2):248-263. doi: 10.1080/15548627.2016.1256932. Epub 2017 Jan 3.
引用本文的文献
1
Therapeutic potential of AAV2-shmTOR gene therapy in reducing retinal inflammation and preserving endothelial Integrity in age-related macular degeneration.AAV2-shmTOR基因疗法在减轻年龄相关性黄斑变性视网膜炎症和维持内皮完整性方面的治疗潜力
Sci Rep. 2025 Mar 19;15(1):9517. doi: 10.1038/s41598-025-93993-4.
2
Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes.常见和罕见变异在亚洲新生血管性年龄相关性黄斑变性亚型中的作用。
Nat Commun. 2023 Sep 11;14(1):5574. doi: 10.1038/s41467-023-41256-z.
3
Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration.Tribbles 同源物 3 介导的 AKT/mTOR 轴在视网膜变性小鼠中的靶向作用。
Cell Death Dis. 2021 Jul 2;12(7):664. doi: 10.1038/s41419-021-03944-w.
4
Dysregulated metabolic pathways in age-related macular degeneration.与年龄相关的黄斑变性中的代谢途径失调。
Sci Rep. 2020 Feb 12;10(1):2464. doi: 10.1038/s41598-020-59244-4.
5
Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.源自年龄相关性黄斑变性患者的干细胞衍生的视网膜色素上皮细胞表现出代谢和基质相互作用减少。
Stem Cells Transl Med. 2020 Mar;9(3):364-376. doi: 10.1002/sctm.19-0321. Epub 2019 Dec 16.
6
Essential Role of mTOR Signaling in Human Retinal Pigment Epithelial Cell Regeneration After Laser Photocoagulation.mTOR 信号在激光光凝后人类视网膜色素上皮细胞再生中的重要作用。
Lasers Med Sci. 2019 Jul;34(5):1019-1029. doi: 10.1007/s10103-018-2692-5. Epub 2018 Nov 29.
7
Mitochondrial disorders and the eye.线粒体疾病与眼睛
Eye Brain. 2011 Sep 26;3:29-47. doi: 10.2147/EB.S16192. eCollection 2011.
8
Multimodal Fundus Imaging of Sodium Iodate-Treated Mice Informs RPE Susceptibility and Origins of Increased Fundus Autofluorescence.碘酸钠处理小鼠的多模态眼底成像揭示视网膜色素上皮的易感性及眼底自发荧光增加的起源
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2152-2159. doi: 10.1167/iovs.17-21557.
9
Mouse mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.小鼠突变揭示了一种涉及线粒体动力学的机制，该机制会导致年龄依赖性视网膜病变。
Elife. 2016 Nov 15;5:e19264. doi: 10.7554/eLife.19264.
10
Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models.使用混合线性模型估计年龄相关性黄斑变性风险的累积通路效应。
BMC Bioinformatics. 2015 Oct 14;16:329. doi: 10.1186/s12859-015-0760-4.
本文引用的文献
1
Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration.与衰老和年龄相关性黄斑变性相关的 RPE 中线粒体 DNA 损伤与修复。
Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3521-9. doi: 10.1167/iovs.10-6163.
2
mTOR: from growth signal integration to cancer, diabetes and ageing.mTOR：从生长信号整合到癌症、糖尿病和衰老。
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35. doi: 10.1038/nrm3025. Epub 2010 Dec 15.
3
mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.mTOR 介导的视网膜色素上皮细胞去分化引发小鼠光感受器变性。
J Clin Invest. 2011 Jan;121(1):369-83. doi: 10.1172/JCI44303. Epub 2010 Dec 6.
4
Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration.线粒体 DNA 损伤作为与年龄相关的黄斑变性的潜在机制。
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5470-9. doi: 10.1167/iovs.10-5429. Epub 2010 May 26.
5
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
6
Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells.β-淀粉样蛋白（1-42）改变视网膜色素上皮细胞的结构和功能。
Aging Cell. 2009 Apr;8(2):162-77. doi: 10.1111/j.1474-9726.2009.00456.x. Epub 2009 Feb 23.
7
Mitochondrial DNA damage and its potential role in retinal degeneration.线粒体DNA损伤及其在视网膜变性中的潜在作用。
Prog Retin Eye Res. 2008 Nov;27(6):596-607. doi: 10.1016/j.preteyeres.2008.09.001. Epub 2008 Sep 23.
8
The genomic response of the retinal pigment epithelium to light damage and retinal detachment.视网膜色素上皮细胞对光损伤和视网膜脱离的基因组反应。
J Neurosci. 2008 Sep 24;28(39):9880-9. doi: 10.1523/JNEUROSCI.2401-08.2008.
9
SOD2 knockdown mouse model of early AMD.早期年龄相关性黄斑变性的超氧化物歧化酶2基因敲低小鼠模型。
Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4407-20. doi: 10.1167/iovs.07-0432.
10
Current concepts in the pathogenesis of age-related macular degeneration.年龄相关性黄斑变性发病机制的当前概念
Arch Ophthalmol. 2004 Apr;122(4):598-614. doi: 10.1001/archopht.122.4.598.
Zotero 插件