Gerosuppressant metformin: less is more.
作者信息
Menendez Javier A, Cufí Sílvia, Oliveras-Ferraros Cristina, Vellon Luciano, Joven Jorge, Vazquez-Martin Alejandro
机构信息
Catalan Institute of Oncology, Girona, Catalonia, Spain.
出版信息
Aging (Albany NY). 2011 Apr;3(4):348-62. doi: 10.18632/aging.100316.
Abstract
摘要
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1
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2
[Metformin slows down ageing processes at the cellular level in SHR mice].
Tsitologiia. 2011;53(2):166-74.
3
Regulation of senescence in cancer and aging.
J Aging Res. 2011 Mar 8;2011:963172. doi: 10.4061/2011/963172.
4
Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.
Cancer Res. 2011 May 1;71(9):3196-201. doi: 10.1158/0008-5472.CAN-10-3471. Epub 2011 Mar 17.
5
Promoter-specific effects of metformin on aromatase transcript expression.
Steroids. 2011 Jul;76(8):768-71. doi: 10.1016/j.steroids.2011.02.041. Epub 2011 Mar 15.
6
If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
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Biochem Biophys Res Commun. 2011 Apr 8;407(2):321-6. doi: 10.1016/j.bbrc.2011.03.013. Epub 2011 Mar 6.
8
Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a.
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9
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Nature. 2011 Feb 17;470(7334):338-9. doi: 10.1038/470338a.
10
Four faces of cellular senescence.
J Cell Biol. 2011 Feb 21;192(4):547-56. doi: 10.1083/jcb.201009094. Epub 2011 Feb 14.
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