Gerosuppressant metformin: less is more.
作者信息
Menendez Javier A, Cufí Sílvia, Oliveras-Ferraros Cristina, Vellon Luciano, Joven Jorge, Vazquez-Martin Alejandro
机构信息
Catalan Institute of Oncology, Girona, Catalonia, Spain.
出版信息
Aging (Albany NY). 2011 Apr;3(4):348-62. doi: 10.18632/aging.100316.
Abstract
摘要
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本文引用的文献
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Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response.二甲双胍激活一种由共济失调毛细血管扩张症突变基因（ATM）/Chk2调节的类似DNA损伤反应。
Cell Cycle. 2011 May 1;10(9):1499-501. doi: 10.4161/cc.10.9.15423.
2
[Metformin slows down ageing processes at the cellular level in SHR mice].[二甲双胍可减缓自发性高血压大鼠（SHR）小鼠细胞水平的衰老进程]
Tsitologiia. 2011;53(2):166-74.
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Regulation of senescence in cancer and aging.癌症与衰老过程中衰老的调控。
J Aging Res. 2011 Mar 8;2011:963172. doi: 10.4061/2011/963172.
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Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.二甲双胍可降低化疗剂量，从而延长涉及多种癌细胞类型的小鼠异种移植物肿瘤缓解时间。
Cancer Res. 2011 May 1;71(9):3196-201. doi: 10.1158/0008-5472.CAN-10-3471. Epub 2011 Mar 17.
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Promoter-specific effects of metformin on aromatase transcript expression.二甲双胍对芳香化酶转录表达的启动子特异性作用。
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