School of Chemistry, University of Leeds, Leeds, UK.
Nanotechnology. 2011 Jun 10;22(23):235604. doi: 10.1088/0957-4484/22/23/235604. Epub 2011 Apr 11.
Well-defined, water-soluble C(60)/micelle hierarchical colloids with varied amounts of C(60) sitting on the surface of micellar cores were prepared via the self-assembly of PS-b-PDMA block copolymer micelles and C(60). The composites can generate a significant amount of reactive oxygen upon irradiation with red light. Cell studies showed that the colloids were either strongly associated with, or internalized by, the cells after 2 h incubation, but did not show obvious toxicity in the dark. In contrast, efficient cell killing was observed when the colloid-incubated cells were exposed to red light. This indicates that the supramolecular colloids are promising as photosensitizers for photodynamic cancer therapy.
通过 PS-b-PDMA 嵌段共聚物胶束和 C(60)的自组装，制备了具有不同数量的 C(60)位于胶束核表面的、形貌明确、水溶性好的 C(60)/胶束分级胶体。这些复合材料在红光照射下能产生大量的活性氧。细胞研究表明，胶体在孵育 2 小时后与细胞强烈结合或被细胞内化，但在黑暗中没有明显的毒性。相比之下，当胶体孵育的细胞暴露于红光下时，观察到有效的细胞杀伤。这表明超分子胶体有望成为光动力癌症治疗的光敏剂。
