Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructures and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China.
Small. 2012 Jul 9;8(13):2070-7. doi: 10.1002/smll.201200158. Epub 2012 Apr 17.
Carboxyfullerenes with different adduct numbers and cage sizes are tested as photosensitizers for photodynamic therapy (PDT). The photodynamic efficiency of these carboxyfullerenes depends mainly on the cage size, C(60) versus C(70) , and to a lesser extent on the adduct numbers. In particular, malonic acid modified C(70) fullerenes are more efficient than their C(60) counterparts as photosensitizers, and the mechanism of cell death induced by C(70) -carboxyfullerene under light irradiation is investigated in detail. The results indicate that cell death occurs via necrosis accompanied by membrane blebbing, which is a unique phenomenon for photosensitizer-induced cell death. Since C(70) -carboxyfullerene displays an efficient PDT property and negligible dark cytotoxicity, it is promising for use in PDT applications, especially in vascular capillary diseases usually occurring under the surface.
不同加成数和笼型大小的羧基富勒烯被用作光动力疗法（PDT）的光敏剂。这些羧基富勒烯的光动力效率主要取决于笼型大小，即 C(60)与 C(70)，而加成数的影响则较小。特别是，丙二酸修饰的 C(70)富勒烯作为光敏剂比其 C(60)对应物更有效，并且详细研究了在光照下 C(70)-羧基富勒烯诱导细胞死亡的机制。结果表明，细胞死亡通过伴有膜泡形成的坏死发生，这是光敏剂诱导细胞死亡的独特现象。由于 C(70)-羧基富勒烯显示出有效的 PDT 性质和可忽略的暗毒性，因此有望用于 PDT 应用，特别是在通常发生在表面下的血管毛细血管疾病中。
