Frank E, Kupfer D J, Bulik C M, Levenson J A
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213.
J Affect Disord. 1990 Nov;20(3):165-72. doi: 10.1016/0165-0327(90)90140-4.
Weight change was examined in 128 depressed outpatients treated successfully with an average dose of 215 mg imipramine and then continued on that treatment regimen for 5 additional months, an average duration of over 33 weeks. More than half the patients experienced a change in weight of 5% or less and only 13.3% experienced a gain of greater than 10%. While males and females did not differ in their pattern of change during acute treatment, females experienced a greater percent change (P less than 0.06) and change in body mass index (P = 0.05) during continuation treatment. The clinical implications of these findings are discussed, especially with respect to the extreme group.
对128名成功接受平均剂量215毫克丙咪嗪治疗的抑郁症门诊患者的体重变化进行了检查，然后继续该治疗方案5个月，平均疗程超过33周。超过一半的患者体重变化在5%或以下，只有13.3%的患者体重增加超过10%。虽然男性和女性在急性治疗期间的变化模式没有差异，但女性在继续治疗期间的百分比变化更大（P小于0.06），体重指数变化（P = 0.05）更大。讨论了这些发现的临床意义，特别是关于极端组的情况。
