Department of Pathology and Forensic Medicine, School of Medicine, University of Kufa, Kufa, Iraq.
Libyan J Med. 2010 Apr 8;5. doi: 10.3402/ljm.v5i0.5059.
Colorectal carcinoma (CRC) is the seventh-most common malignancy and is the main cause of death in Iraq. The incidence of this cancer has increased sharply after the invasion of Iraq in 2003.
To estimate immunohistochemical expression of vascular endothelial growth factor (VEGF) in CRC in relation to other parameters, such as grade and stage of tumour.
Formalin fixed, paraffin-embedded blocks from 52 patients (27 male and 25 female) with CRC were included in this study. A group of 22 patients with non-cancerous colonic tissues were included as a control group. Avidin-biotin complex method was employed for immunohistochemical detection of VEGF.
VEGF immuno-expression was positive in 51.9% of CRC, while it was 18.2% in the normal colonic tissue (p <0.05). VEGF immunostaining was positively correlated with grade of colonic malignancy (p <0.05).
These findings provide further evidence for the role of VEGF in the carcinogenesis of CRC. However, VEGF could not be well correlated with stage of tumour and hence may be a poor prognostic parameter of state of malignancy of colonic carcinoma.
结直肠癌（CRC）是第七大常见恶性肿瘤，也是伊拉克死亡的主要原因。2003 年伊拉克被入侵后，这种癌症的发病率急剧上升。
评估血管内皮生长因子（VEGF）在结直肠癌中的免疫组织化学表达与肿瘤分级和分期等其他参数的关系。
本研究纳入了 52 例结直肠癌患者（27 名男性和 25 名女性）的福尔马林固定、石蜡包埋块。将 22 例非癌性结肠组织患者作为对照组。采用亲和素-生物素复合物法检测 VEGF 的免疫组织化学表达。
CRC 中 VEGF 免疫表达阳性率为 51.9%，而正常结肠组织中的阳性率为 18.2%（p<0.05）。VEGF 免疫染色与结肠恶性程度呈正相关（p<0.05）。
这些发现为 VEGF 在结直肠癌发生中的作用提供了进一步的证据。然而，VEGF 与肿瘤分期不能很好地相关，因此可能是结直肠癌恶性状态的预后不良参数。
