银催化的通过级联氧化偶联-环化策略合成 4-取代苯并呋喃。

Silver-catalyzed synthesis of 4-substituted benzofurans via a cascade oxidative coupling-annulation protocol.

机构信息

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.

出版信息

Chem Commun (Camb). 2011 May 21;47(19):5626-8. doi: 10.1039/c1cc10137d. Epub 2011 Apr 11.

Abstract

A facile synthesis of 4-indole benzofurans from the one-pot reaction of 4-alkyl-2-ynylphenols and indoles via a hypervalent iodine-induced oxidative dearomatization, a silver-catalyzed cascade Michael addition-annulation, and an aromatization is reported.

摘要

本文报道了一种通过高价碘诱导的氧化去芳构化、银催化的级联迈克尔加成-环化和芳构化反应，从 4-烷基-2-炔基苯酚和吲哚一锅反应中简便合成 4-吲哚苯并呋喃的方法。