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合成生物学中的生命概念。

The conception of life in synthetic biology.

机构信息

University of Zurich, IBME, Pestalozzistr. 24, 8032, Zurich, Switzerland.

出版信息

Sci Eng Ethics. 2012 Dec;18(4):757-74. doi: 10.1007/s11948-011-9269-z. Epub 2011 Apr 12.

Abstract

The phrase 'synthetic biology' is used to describe a set of different scientific and technological disciplines, which share the objective to design and produce new life forms. This essay addresses the following questions: What conception of life stands behind this ambitious objective? In what relation does this conception of life stand to that of traditional biology and biotechnology? And, could such a conception of life raise ethical concerns? Three different observations that provide useful indications for the conception of life in synthetic biology will be discussed in detail: 1. Synthetic biologists focus on different features of living organisms in order to design new life forms, 2. Synthetic biologists want to contribute to the understanding of life, and 3. Synthetic biologists want to modify life through a rational design, which implies the notions of utilising, minimising/optimising, varying and overcoming life. These observations indicate a tight connection between science and technology, a focus on selected aspects of life, a production-oriented approach to life, and a design-oriented understanding of life. It will be argued that through this conception of life synthetic biologists present life in a different light. This conception of life will be illustrated by the metaphor of a toolbox. According to the notion of life as a toolbox, the different features of living organisms are perceived as various rationally designed instruments that can be used for the production of the living organism itself or secondary products made by the organism. According to certain ethical positions this conception of life might raise ethical concerns related to the status of the organism, the motives of the scientists and the role of technology in our society.

摘要

“合成生物学”一词被用来描述一系列不同的科学和技术学科,这些学科都有一个共同的目标,即设计和生产新的生命形式。本文探讨了以下问题:这一雄心勃勃的目标背后是什么样的生命概念?这种生命概念与传统生物学和生物技术的关系如何?以及,这种生命概念是否会引发伦理问题?本文将详细讨论三个有助于理解合成生物学中生命概念的观察结果:1. 合成生物学家专注于生物体的不同特征,以设计新的生命形式;2. 合成生物学家希望为理解生命做出贡献;3. 合成生物学家希望通过理性设计来改造生命,这意味着利用、最小化/优化、改变和克服生命的概念。这些观察结果表明,科学与技术之间存在紧密联系,关注生命的某些方面,采用以生产为导向的方法,以及以设计为导向的生命理解。本文将论证,通过这种生命概念,合成生物学家以不同的方式呈现生命。通过这个生命概念的工具盒隐喻来举例说明。根据工具盒的生命概念,生物体的不同特征被视为各种理性设计的工具,可以用于生产生物体本身或生物体产生的次级产品。根据某些伦理立场,这种生命概念可能会引发与生物体的地位、科学家的动机以及技术在我们社会中的作用有关的伦理问题。

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