King J W, Taylor E M, Crow S D, White M C, Todd J R, Poe M B, Conrad S A, Gelder F B
Department of Medicine, Louisiana State University Medical Center, Shreveport 71130-3932.
Rev Infect Dis. 1990 Nov-Dec;12(6):1035-43. doi: 10.1093/clinids/12.6.1035.
Although hepatitis B vaccine reliably induces immunity to hepatitis B virus, the expense of intramuscular (im) vaccination with this product has limited its use. To determine if a smaller, less expensive, intradermal (id) dose of hepatitis B vaccine would be an effective alternative, we compared the response of antibody to hepatitis B surface antigen (anti-HBs) following im vaccination to that following id vaccination. Volunteers who were seronegative for antibody to hepatitis B core antigen were enrolled in the study and received either im or id vaccine. A total of 108 subjects received three 1-mL im injections of hepatitis B vaccine, and another 110 subjects received four 0.1-mL id injections of the vaccine. Similar rates of seroconversion occurred; greater than or equal to 10 mIU of anti-HBs/mL was noted following either three im or three id vaccinations. Furthermore, 2 years after initiation of vaccination, the serum concentration of anti-HBs for id vaccine recipients was similar to that for im vaccine recipients.
尽管乙肝疫苗能可靠地诱导对乙肝病毒的免疫力，但使用该产品进行肌内注射的费用限制了其应用。为了确定较小剂量、成本较低的皮内注射乙肝疫苗是否为有效的替代方案，我们比较了肌内注射疫苗和皮内注射疫苗后，受试者对乙肝表面抗原抗体（抗-HBs）的反应。乙肝核心抗原抗体血清学阴性的志愿者参与了该研究，并分别接受了肌内注射或皮内注射疫苗。共有108名受试者接受了三次1毫升的乙肝疫苗肌内注射，另有110名受试者接受了四次0.1毫升的疫苗皮内注射。两组的血清转化率相似；三次肌内注射或三次皮内注射后，抗-HBs均达到或超过10 mIU/mL。此外，在开始接种疫苗2年后，皮内注射疫苗的受试者血清抗-HBs浓度与肌内注射疫苗的受试者相似。
