Department of Biochemistry, J. N. Medical College, Nehru nagar, Belgaum - Karnataka, India.
Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):9-14.
Expedited research on Obesity has confirmed that, adipose tissue is highly active in secreting a variety of proteins, one among them is visfatin. It was originally identified as Pre B cell Colony Enhancing Factor (PBEF), to be secreted by the lymphocytes and can act as a cytokine with immune regulatory action. Besides, it acts as Nicotinamide phosphoribosyl transferase (Nampt), an enzyme involved in the NAD+ salvage pathway. It has been shown to help in the regulation of glucose homeostasis, but whether it binds to insulin receptor and exerts insulin mimetic activity is still a controversy. Visfatin has antiapoptotic activity and has a regulatory role in inflammation. Several studies have identified changes in the circulatory levels of visfatin in diseases. Notable among them are obesity, diabetes mellitus, kidney diseases and bone disorders. It is a molecule of clinical relevance and could be a promising biomarker with diagnostic and prognostic significance.
肥胖症的快速研究已经证实，脂肪组织在分泌各种蛋白质方面非常活跃，其中一种是内脂素。它最初被鉴定为前 B 细胞集落增强因子（PBEF），由淋巴细胞分泌，可作为具有免疫调节作用的细胞因子。此外，它还作为烟酰胺磷酸核糖转移酶（Nampt）发挥作用，Nampt 是 NAD+补救途径中涉及的一种酶。已经表明它有助于调节葡萄糖稳态，但它是否与胰岛素受体结合并发挥胰岛素模拟活性仍存在争议。内脂素有抗凋亡活性，并在炎症中起调节作用。几项研究已经确定了循环中内脂素水平在疾病中的变化。其中值得注意的是肥胖症、糖尿病、肾脏疾病和骨骼疾病。它是一种具有临床相关性的分子，可能是一种具有诊断和预后意义的有前途的生物标志物。
