Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China.
Int J Cancer. 2012 Mar 1;130(5):1093-7. doi: 10.1002/ijc.26130. Epub 2011 Aug 8.
Interleukin-23 (IL-23)/IL-23 receptor (IL-23R) is essential for Th17 cell-mediated immune response, involved in autoimmune diseases and cancer pathogenesis. Two potentially functional genetic single nucleotide polymorphisms (SNPs; IL-23R rs6682925 T>C and rs1884444 T>G) were found to contribute to cancer susceptibility. In our study, we conducted a case-control study including 1,645 patients with esophageal cancer and 1,694 cancer-free controls in a Chinese population to assess the association between the two SNPs and the risk of esophageal cancer. We found that IL-23R rs6682925 TC/CC and rs1884444 TG/GG variant genotypes were associated with significantly increased risk of esophageal cancer [rs1884444: adjusted odds ratio (OR) = 1.16, 95% confidence intervals (CIs) =1.01-1.33; rs6682925: adjusted OR = 1.23, 95% CIs = 1.07-1.42], compared to their corresponding wild-type homozygotes. Furthermore, the increased risks associated with the two SNPs were independent from smoking and alcohol drinking status. These findings indicated that genetic variants in IL-23R may contribute to esophageal cancer risk in our Chinese population.
白细胞介素-23（IL-23）/IL-23 受体（IL-23R）对于 Th17 细胞介导的免疫反应至关重要，参与自身免疫性疾病和癌症的发病机制。已经发现两个潜在的功能性遗传单核苷酸多态性（SNP；IL-23R rs6682925 T>C 和 rs1884444 T>G）与癌症易感性有关。在我们的研究中，我们在中国人群中进行了一项病例对照研究，包括 1645 名食管癌患者和 1694 名无癌症对照，以评估这两个 SNP 与食管癌风险之间的关联。我们发现，IL-23R rs6682925 TC/CC 和 rs1884444 TG/GG 变异基因型与食管癌的风险显著增加相关[rs1884444：调整后的优势比（OR）=1.16，95%置信区间（CI）=1.01-1.33；rs6682925：调整 OR = 1.23，95% CI = 1.07-1.42]，与相应的野生型纯合子相比。此外，与这两个 SNP 相关的风险增加与吸烟和饮酒状况无关。这些发现表明，IL-23R 中的遗传变异可能导致我们中国人群的食管癌风险增加。
