Department of Internal Medicine Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Department of Internal Medicine Oncology, The Fifth People's Hospital of Qinghai Province, Xining, Qinghai, China.
Mol Carcinog. 2019 Oct;58(10):1822-1831. doi: 10.1002/mc.23069. Epub 2019 Jun 13.
Single nucleotide polymorphisms (SNPs) in interleukin-23 receptor (IL23R) are involved in the pathogenesis of many cancers and autoimmune diseases. IL23R gene is still controversial in the study of esophageal cancer. The aim of this research is to investigate the influence of IL23R SNPs on the risk of esophageal cancer. Five hundred six esophageal cancer and 507 controls frequency matched by age and gender were conducted, and the genotypes were determined by the Agena MassARRAY. Logistic regression analysis was used to evaluate the odd ratios (ORs) and 95% confidence intervals (CIs) of rs1884444 and rs6682925 with susceptibility of esophageal cancer. A total of 30 articles are eligible. Pooled ORs and the 95% CI were calculated using the random-effect model. Database predicts the expression of IL23R gene in esophageal cancer. IL23R rs1884444 allele G decreased the risk of esophageal cancer under allele, genotype, and additive models (allele model: OR = 0.82, 95% CI: 0.68-0.98, P = .032; genotype model: OR = 0.65, 95% CI: 0.44-0.97, P = .035; additive model: OR = 0.82, 95% CI: 0.68-0.98, P = .031). Meta-analysis shown that IL23R rs1884444 increased the risk of overall disease in allele model (OR = 1.16, 95% CI: 1.08-1.25, P < .001), and also increased the risk of gastrointestinal tumor (OR = 1.18, 95% CI: 1.05-1.31, P = .005). The database analysis showed that the expression of IL23R gene was upregulated in esophageal cancer tissues. IL23R rs1884444 may play an important role in the susceptibility of esophageal cancer.
单核苷酸多态性（SNPs）在白细胞介素-23 受体（IL23R）中参与许多癌症和自身免疫性疾病的发病机制。IL23R 基因在食管癌的研究中仍存在争议。本研究旨在探讨 IL23R SNPs 对食管癌风险的影响。对 506 例食管癌和 507 例年龄和性别匹配的对照进行了研究，通过 Agena MassARRAY 确定基因型。采用 logistic 回归分析评估 rs1884444 和 rs6682925 与食管癌易感性的比值比（OR）和 95%置信区间（CI）。共纳入 30 篇符合条件的文章。使用随机效应模型计算合并 OR 和 95%CI。数据库预测食管癌中 IL23R 基因的表达。IL23R rs1884444 等位基因 G 在等位基因、基因型和加性模型下降低了食管癌的风险（等位基因模型：OR=0.82，95%CI：0.68-0.98，P=0.032；基因型模型：OR=0.65，95%CI：0.44-0.97，P=0.035；加性模型：OR=0.82，95%CI：0.68-0.98，P=0.031）。荟萃分析显示，IL23R rs1884444 在等位基因模型中增加了总体疾病的风险（OR=1.16，95%CI：1.08-1.25，P<0.001），并且还增加了胃肠道肿瘤的风险（OR=1.18，95%CI：1.05-1.31，P=0.005）。数据库分析显示，IL23R 基因在食管癌组织中表达上调。IL23R rs1884444 可能在食管癌易感性中发挥重要作用。
