Obesity Research Center, St. Luke's-Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY 10025, USA.
Am J Hum Biol. 2011 May-Jun;23(3):333-8. doi: 10.1002/ajhb.21137. Epub 2010 Dec 22.
The specific resting metabolic rates (K(i) , in kcal/kg per day) of major organs and tissues in the Reference Man were suggested in 1992 by Elia: 200 for liver, 240 for brain, 440 for heart and kidneys, 13 for skeletal muscle, 4.5 for adipose tissue and 12 for the residual mass. However, it is unknown whether gender influences the K(i) values. The aim of the present study was to compare the K(i) values observed in nonelderly nonobese men to the corresponding values in women.
Elia's K(i) values were evaluated based on a mechanistic model: REE = Σ(K(i) × T(i) ), where REE is whole-body resting energy expenditure measured by indirect calorimetry and T(i) is the mass of major organs and tissues measured by magnetic resonance imaging. Marginal 95% confidence intervals (CIs) for the model-estimated K(i) values were calculated by stepwise univariate regression analysis. Subjects were nonelderly (age 20-49 years) nonobese (BMI 18.5-29.9 kg/m(2) ) men (n = 49) and women (n = 57).
The measured REE (REEm) and the mass of major organs and skeletal muscle were all greater in the men than in women. The predicted REE by Elia's K(i) values were correlated with REEm in men (r = 0.87) and women (r = 0.86, both P < 0.001). Elia's K(i) values were within the range of 95% CIs for both men and women groups, revealing that gender adjustment is not necessary.
Elia's proposed adult K(i) values are valid in both nonelderly nonobese men and women. Further studies are needed to explore the potential influences of age and obesity on K(i) values in humans.
1992 年，Elia 提出了参考人体内主要器官和组织的特定静息代谢率（K(i)，以千卡/公斤/天为单位）：肝脏为 200，大脑为 240，心脏和肾脏为 440，骨骼肌为 13，脂肪组织为 4.5，剩余质量为 12。然而，目前尚不清楚性别是否会影响 K(i) 值。本研究旨在比较非老年非肥胖男性和女性的 K(i) 值。
基于一种机械模型评估 Elia 的 K(i) 值：REE=Σ（K(i)×T(i)），其中 REE 是通过间接测热法测量的全身静息能量消耗，T(i) 是通过磁共振成像测量的主要器官和组织的质量。通过逐步单变量回归分析计算模型估计的 K(i) 值的边缘 95%置信区间（CI）。受试者为非老年（20-49 岁）非肥胖（BMI 18.5-29.9kg/m(2)）男性（n=49）和女性（n=57）。
男性的测量 REE（REEm）和主要器官及骨骼肌的质量均大于女性。Elia 的 K(i) 值预测的 REE 与男性（r=0.87，P<0.001）和女性（r=0.86，P<0.001）的 REEm 相关。Elia 的 K(i) 值在男性和女性组的 95%CI 范围内，表明不需要进行性别调整。
Elia 提出的成人 K(i) 值在非老年非肥胖男性和女性中均有效。需要进一步研究探讨年龄和肥胖对人类 K(i) 值的潜在影响。
