肾上腺素能神经支配与肾上腺素能机制。一项关于人类尿道的研究。

Adrenergic innervation and adrenergic mechanisms. A study of the human urethra.

作者信息

Ek A

出版信息

Acta Pharmacol Toxicol (Copenh). 1978;43 Suppl 2:35-40. doi: 10.1111/j.1600-0773.1978.tb03217.x.

DOI:10.1111/j.1600-0773.1978.tb03217.x

Abstract

Adrenergic nerves studied by a histochemical method were uniformly distributed along the whole extent of the male and female urethra. Corresponding to the adrenergic innervation a preponderance of contraction-mediating alpha-adrenoceptors was found in vitro studying urethral strips and in vivo recording the urethral closure pressure profile (UCPP). Norephedrine significantly reduced incontinence and increased UCPP in stress-incontinent women.

摘要

采用组织化学方法研究发现，肾上腺素能神经沿男性和女性尿道全程呈均匀分布。与肾上腺素能神经支配相对应，在体外对尿道条进行研究以及在体内记录尿道闭合压曲线（UCPP）时，均发现介导收缩的α-肾上腺素能受体占优势。去甲麻黄碱可显著减少压力性尿失禁女性的尿失禁情况，并提高其尿道闭合压。