Tillib S V
Mol Biol (Mosk). 2011 Jan-Feb;45(1):77-85.
This short review provides an introduction to the rapidly developing field of generation and utilization of "camel nanoantibodies" (or "nanobodies"). The term "nanoantibody" or "nanobody" was given to single-domain variable fragments of special type of antibodies that naturally exist (in addition to classical types of antibodies) in blood of Camelidae family animals and in some chondrichthyan fishes. The existence of very efficient technology of nanobody generation and some very useful characteristic features promise a big potential for their use in immunobiotechnology and medicine.
本简短综述介绍了快速发展的“骆驼纳米抗体”(或“纳米体”)生成与应用领域。“纳米抗体”一词指的是骆驼科动物血液以及一些软骨鱼类中天然存在的(除经典抗体类型外)特殊类型抗体的单域可变片段。纳米体生成的高效技术及其一些非常有用的特性预示着它们在免疫生物技术和医学中的巨大应用潜力。