• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

“骆驼纳米抗体”是用于研究、诊断和治疗的有效工具。

["Camel nanoantibody" is an efficient tool for research, diagnostics and therapy].

作者信息

Tillib S V

出版信息

Mol Biol (Mosk). 2011 Jan-Feb;45(1):77-85.

PMID:21485499
Abstract

This short review provides an introduction to the rapidly developing field of generation and utilization of "camel nanoantibodies" (or "nanobodies"). The term "nanoantibody" or "nanobody" was given to single-domain variable fragments of special type of antibodies that naturally exist (in addition to classical types of antibodies) in blood of Camelidae family animals and in some chondrichthyan fishes. The existence of very efficient technology of nanobody generation and some very useful characteristic features promise a big potential for their use in immunobiotechnology and medicine.

摘要

本简短综述介绍了快速发展的“骆驼纳米抗体”(或“纳米体”)生成与应用领域。“纳米抗体”一词指的是骆驼科动物血液以及一些软骨鱼类中天然存在的(除经典抗体类型外)特殊类型抗体的单域可变片段。纳米体生成的高效技术及其一些非常有用的特性预示着它们在免疫生物技术和医学中的巨大应用潜力。

相似文献

1
["Camel nanoantibody" is an efficient tool for research, diagnostics and therapy].“骆驼纳米抗体”是用于研究、诊断和治疗的有效工具。
Mol Biol (Mosk). 2011 Jan-Feb;45(1):77-85.
2
Analysis of heavy and light chain sequences of conventional camelid antibodies from Camelus dromedarius and Camelus bactrianus species.分析来自单峰驼和双峰驼的常规骆驼抗体的重链和轻链序列。
J Immunol Methods. 2014 Mar;405:35-46. doi: 10.1016/j.jim.2014.01.003. Epub 2014 Jan 18.
3
Production of novel recombinant single-domain antibodies against tandem repeat region of MUC1 mucin.针对粘蛋白1(MUC1)串联重复区域的新型重组单域抗体的制备。
Hybrid Hybridomics. 2004 Jun;23(3):151-9. doi: 10.1089/1536859041224334.
4
The specific variable domain of camel heavy-chain antibodies is encoded in the germline.骆驼重链抗体的特定可变结构域是在种系中编码的。
J Mol Biol. 1998 Jan 23;275(3):413-8. doi: 10.1006/jmbi.1997.1477.
5
Nanobodies: natural single-domain antibodies.纳米抗体:天然单域抗体。
Annu Rev Biochem. 2013;82:775-97. doi: 10.1146/annurev-biochem-063011-092449. Epub 2013 Mar 13.
6
Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire.骆驼重链抗体:多样的种系V(H)H和特定机制扩大了抗原结合库。
EMBO J. 2000 Mar 1;19(5):921-30. doi: 10.1093/emboj/19.5.921.
7
General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.人源化骆驼科单域抗体的通用策略及通用人源化纳米抗体支架的鉴定
J Biol Chem. 2009 Jan 30;284(5):3273-3284. doi: 10.1074/jbc.M806889200. Epub 2008 Nov 14.
8
Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies.鉴定用于移植骆驼单域抗体非典型抗原结合环的通用VHH框架。
J Mol Biol. 2005 Sep 23;352(3):597-607. doi: 10.1016/j.jmb.2005.07.038.
9
Over expression of anti-MUC1 single-domain antibody fragments in the yeast Pichia pastoris.抗MUC1单域抗体片段在毕赤酵母中的过表达。
Mol Immunol. 2006 Feb;43(5):426-35. doi: 10.1016/j.molimm.2005.03.003. Epub 2005 Mar 25.
10
Heavy-chain antibodies in Camelidae; a case of evolutionary innovation.骆驼科动物中的重链抗体;一个进化创新的案例。
Immunogenetics. 2002 Apr;54(1):39-47. doi: 10.1007/s00251-002-0433-0. Epub 2002 Feb 26.

引用本文的文献

1
Neutralization of the Pandemic Influenza A/H1N1 Virus with Humanized Nanobodies (VHH).利用人源化纳米抗体(VHH)中和甲型H1N1大流行性流感病毒
Antibodies (Basel). 2025 May 16;14(2):42. doi: 10.3390/antib14020042.
2
Synergistic combination of targeted nano-nuclear-reactors and anti-PD-L1 nanobodies evokes persistent T cell immune activation for cancer immunotherapy.靶向纳米核反应堆与抗 PD-L1 纳米抗体的协同组合引发持久的 T 细胞免疫激活,用于癌症免疫治疗。
J Nanobiotechnology. 2022 Dec 10;20(1):521. doi: 10.1186/s12951-022-01736-8.
3
Development of a Bispecific Nanobody Targeting CD20 on B-Cell Lymphoma Cells and CD3 on T Cells.
一种靶向B细胞淋巴瘤细胞上的CD20和T细胞上的CD3的双特异性纳米抗体的研发。
Vaccines (Basel). 2022 Aug 17;10(8):1335. doi: 10.3390/vaccines10081335.
4
Comparison of the oxidative respiratory burst and mitogen-induced leukocyte responses of camels, goats, sheep, and cows.骆驼、山羊、绵羊和奶牛氧化呼吸爆发及丝裂原诱导的白细胞反应的比较。
Vet World. 2022 Jun;15(6):1398-1407. doi: 10.14202/vetworld.2022.1398-1407. Epub 2022 Jun 7.
5
Development of camelid monoclonal nanobody against SLC39A6 zinc transporter protein.抗SLC39A6锌转运蛋白的骆驼科单克隆纳米抗体的研发
Iran J Basic Med Sci. 2021 Dec;24(12):1726-1733. doi: 10.22038/IJBMS.2021.58542.13003.
6
Selection and identification of single-domain antibody against Peste des Petits Ruminants virus.抗小反刍兽疫病毒单域抗体的筛选与鉴定。
J Vet Sci. 2021 Jul;22(4):e45. doi: 10.4142/jvs.2021.22.e45. Epub 2021 Jun 2.
7
Nano-immunotherapy for each stage of cancer cellular immunity: which, why, and what?针对癌症细胞免疫各阶段的纳米免疫疗法:哪些、为何以及是什么?
Theranostics. 2021 Jun 1;11(15):7471-7487. doi: 10.7150/thno.59953. eCollection 2021.
8
The Therapeutic Potential of Nanobodies.纳米抗体的治疗潜力。
BioDrugs. 2020 Feb;34(1):11-26. doi: 10.1007/s40259-019-00392-z.
9
The distributive and structural characteristics of bronchus-associated lymphoid tissue (BALT) in Bactrian camels ().双峰驼支气管相关淋巴组织(BALT)的分布及结构特征() 。 你提供的原文括号内内容不完整,请补充完整以便能准确翻译。
PeerJ. 2019 Mar 11;7:e6571. doi: 10.7717/peerj.6571. eCollection 2019.
10
The Distribution of SIgA and IgG Antibody-Secreting Cells in the Small Intestine of Bactrian Camels (Camelus bactrianus) of Different Ages.不同年龄双峰驼(Camelus bactrianus)小肠中分泌型免疫球蛋白A和免疫球蛋白G抗体分泌细胞的分布
PLoS One. 2016 Jun 1;11(6):e0156635. doi: 10.1371/journal.pone.0156635. eCollection 2016.