Devbhuti Pritesh, Sikdar Debasis, Saha Achintya, Sengupta Chandana
Division of Medicinal and Pharmaceutical Chemistry, Dept. of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India.
Acta Pol Pharm. 2011 Jan-Feb;68(1):15-22.
A drug may cause alteration in blood-lipid profile and induce lipid peroxidation phenomena on administration in the body. Antioxidant may play beneficial role to control the negative alteration in lipid profile and lipid peroxidation. In view of this context, the present in vivo study was carried out to evaluate the role of ascorbic acid as antioxidant on netilmicin-induced alteration of blood lipid profile and peroxidation parameters. Rabbits were used as experimental animals and blood was collected to estimate blood-lipid profiles, such as total cholesterol (TCh), high density lipoprotein cholesterol (HDL-Ch), low density lipoprotein cholesterol (LDL-Ch), very low density lipoprotein cholesterol (VLDL-Ch), triglycerides (Tg), phospholipids (PL), and total lipids (TL), as well as peroxidation parameters, such as malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), reduced glutathione (GSH) and nitric oxide (NO). The results revealed that netilmicin caused significant enhancement of MDA, HNE, TCh, LDL-Ch, VLDL-Ch, Tg levels and reduction in GSH, NO, HDL-Ch, PL, TL levels. On co-administration, ascorbic acid was found to be effective in reducing netilmicin-induced negative alterations of the above parameters.
药物在体内给药时可能会导致血脂谱改变并引发脂质过氧化现象。抗氧化剂可能在控制血脂谱和脂质过氧化的负面改变方面发挥有益作用。鉴于此，开展了本体内研究，以评估抗坏血酸作为抗氧化剂对奈替米星诱导的血脂谱改变和过氧化参数的作用。将兔子用作实验动物，并采集血液以评估血脂谱，如总胆固醇（TCh）、高密度脂蛋白胆固醇（HDL-Ch）、低密度脂蛋白胆固醇（LDL-Ch）、极低密度脂蛋白胆固醇（VLDL-Ch）、甘油三酯（Tg）、磷脂（PL）和总脂质（TL），以及过氧化参数，如丙二醛（MDA）、4-羟基-2-壬烯醛（HNE）、还原型谷胱甘肽（GSH）和一氧化氮（NO）。结果显示，奈替米星导致MDA、HNE、TCh、LDL-Ch、VLDL-Ch、Tg水平显著升高，GSH、NO、HDL-Ch、PL、TL水平降低。同时给药时，发现抗坏血酸可有效减轻奈替米星诱导的上述参数的负面改变。
