Chemical Laboratory, Central Leather Research Institute (Council of Scientific and Industrial Research, India), Adyar, Chennai 600020, India.
J Biomed Nanotechnol. 2011 Feb;7(1):89-90. doi: 10.1166/jbn.2011.1216.
The application of carbon nanotubes (CNT) in the area of biology such as Drug delivery vehicle and Biosensors calls for the basic understanding of the CNT's with biological macromolecules like proteins, DNA, Carbohydrates and lipids. CNT is known to be highly hydrophobic in nature. Our study reveals that the inherent hydrophobic nature of CNT is capable of disturbing the alpha-helical protein secondary structure. Thus our study provides mechanistic understanding of the loss in the alpha-helicity of the proteins in the presence of CNT. Our study reveals that the nanomaterials should be suitably modified for biological applications.
碳纳米管（CNT）在生物学领域的应用，如药物输送载体和生物传感器，需要对 CNT 与生物大分子（如蛋白质、DNA、碳水化合物和脂质）的基本理解。众所周知，CNT 在本质上是高度疏水的。我们的研究表明，CNT 的固有疏水性质能够干扰蛋白质的α-螺旋二级结构。因此，我们的研究提供了在 CNT 存在下蛋白质α-螺旋性丧失的机制理解。我们的研究表明，纳米材料应该进行适当的修饰，以应用于生物学领域。
