Chemical Laboratory, Central Leather Research Institute (CSIR), Adyar, Chennai 600020, India.
J Biomed Nanotechnol. 2011 Feb;7(1):186-7. doi: 10.1166/jbn.2011.1261.
In variety of biological applications carbon nano materials interact with different biological macromolecules, such as proteins, carbohydrates and nucleic acids. In this study carbon nanotube (CNT) has been used as the model for carbon nanomaterials. Since, collagen is a large protein; model collagen like peptide (CPs) has been used to understand the interaction between CNT and collagen. Molecular dynamics (MD) simulation showed that the hydrophobic-hydrophobic interaction of the CNT-CPs play a crucial role in attracting the CPs towards the CNT. No structural aberrations occured in collagen upon interaction with CNT and hence CNT can be employed in the tissue engineering applications.
在各种生物应用中，碳纳米材料与不同的生物大分子相互作用，如蛋白质、碳水化合物和核酸。在本研究中，碳纳米管 (CNT) 被用作碳纳米材料的模型。由于胶原蛋白是一种大型蛋白质，因此使用模型胶原蛋白样肽 (CPs) 来了解 CNT 与胶原蛋白之间的相互作用。分子动力学 (MD) 模拟表明，CNT-CPs 之间的疏水-疏水相互作用在吸引 CPs 朝向 CNT 方面起着至关重要的作用。CNT 与胶原蛋白相互作用后，胶原蛋白没有发生结构异常，因此 CNT 可以应用于组织工程应用。
