Universidad Peruana Cayetano Heredia, Lima, Peru.
Andrologia. 2011 Jun;43(3):189-95. doi: 10.1111/j.1439-0272.2010.01046.x. Epub 2011 Jan 19.
Life at high altitudes (>4000 m) is associated with higher erythropoiesis. Haemoglobin ≥21 g dl(-1) is considered as excessive erythrocytosis and is a sign of chronic mountain sickness (CMS). The present study was designed to determine an association between serum testosterone (T) and serum oestradiol (E(2) ) levels with the score of CMS. One hundred and seventeen men natives from low altitude (150 m) and 103 men natives from high altitude (4340 m) were studied. The presence of breathlessness or palpitations, sleep disturbance, cyanosis, dilatation of veins, paraesthesia, headaches, tinnitus and Hb ≥21 g dl(-1) , have been included for the CMS score. Men living at high altitude had higher CMS score (P < 0.001), serum T (P < 0.05) and serum E(2) levels (P < 0.04) and had lower serum luteinising hormone levels (P < 0.005) than men living at sea level. At high altitude, the group with the highest CMS score (≥10) showed higher chronological age, SpO(2) , serum T and ratio T/E(2) than the group with CMS score of ≤4. Some symptoms of CMS as sleep disorders and paraesthesia were more related to high serum T level; cyanosis was more related to higher haemoglobin values. In conclusion, higher serum T levels were associated to higher scores of CMS.
高海拔（>4000 米）生活与更高的红细胞生成有关。血红蛋白≥21g dl(-1)被认为是红细胞增多症过度，是慢性高山病（CMS）的标志。本研究旨在确定血清睾酮（T）和血清雌二醇（E(2)）水平与 CMS 评分之间的关系。研究了 117 名来自低海拔（150 米）的男性和 103 名来自高海拔（4340 米）的男性。CMS 评分包括呼吸困难或心悸、睡眠障碍、发绀、静脉扩张、感觉异常、头痛、耳鸣和 Hb≥21g dl(-1)。生活在高海拔地区的男性 CMS 评分较高（P<0.001），血清 T（P<0.05）和血清 E(2)水平较高（P<0.04），血清黄体生成素水平较低（P<0.005）。在高海拔地区，CMS 评分最高（≥10）的组比 CMS 评分≤4 的组具有更高的实际年龄、SpO(2)、血清 T 和 T/E(2)比值。一些 CMS 症状如睡眠障碍和感觉异常与较高的血清 T 水平更相关；发绀与较高的血红蛋白值更相关。总之，较高的血清 T 水平与 CMS 评分较高有关。
