The Kidney Transplantation Centre of HangZhou JiuLiSong Hospital, Hangzhou, China.
Andrologia. 2011 Jun;43(3):203-7. doi: 10.1111/j.1439-0272.2010.01052.x. Epub 2011 Jan 19.
We investigated factors such as time span between transplantation and having offspring, the dosage of immunosuppressive agents during fertilisation and the effects of fertilisation on recipient's renal allograft function in 212 male recipients registered at eight Chinese organ transplantation centres. Our results are as follows: the 212 male renal allograft recipients conceived with their wives between 15 and 204 months after transplantation. The wives who became pregnant at 15-24 months after the renal transplantation gave birth to a total of 20 babies with an average weight of 3115 ± 517 g, of which 3 (15.0%) were premature. The wives who became pregnant at 25-204 months after the renal transplantation gave birth to a total of 196 babies with an average weight of 3384 ± 438 g, of which 6 (3.1%) were premature. All recipients had normal renal function during the fertile period. In conclusion, the fertility capacity of male renal allograft recipients was associated with the time after transplantation and the dose of immunosuppressive agents used during fertilisation. It might be helpful to have a fertility capacity evaluation before fertilisation. There were no effects of fertility on renal allograft function.
我们在 8 家中国器官移植中心登记的 212 名男性肾移植受者中，调查了移植后与生育子女之间的时间间隔、受精期间免疫抑制剂的剂量以及受精对受者肾移植功能的影响等因素。结果如下：212 名男性肾移植受者在移植后 15 至 204 个月与妻子受孕。肾移植后 15-24 个月怀孕的妻子共生育 20 名婴儿，平均体重 3115±517g，其中 3 名（15.0%）为早产儿。肾移植后 25-204 个月怀孕的妻子共生育 196 名婴儿，平均体重 3384±438g，其中 6 名（3.1%）为早产儿。所有受者在生育期肾功能正常。结论：男性肾移植受者的生育能力与移植后时间和受精期间使用的免疫抑制剂剂量有关。在受精前进行生育能力评估可能会有所帮助。生育对肾移植功能没有影响。
