Veterinary Research Institute, Brno, Czech Republic.
Andrologia. 2011 Aug;43(4):286-91. doi: 10.1111/j.1439-0272.2010.01057.x. Epub 2011 Mar 23.
Obesity can adversely affect human health, including fertility. While obesity can disturb the hormonal profile of the female organism and is associated with fertility loss, little is known about what effect male obesity has on fertility. The present study analysed sperm samples of 153 donors. The men were selected from couples attending an infertility clinic, who had tried for 12 months or more to achieve pregnancy without success. The age of the men under investigation was recorded, and their body mass index (BMI) was calculated. All semen samples were assessed for volume, concentration, motility and morphology. Sperm chromatin integrity was measured by sperm chromatin structure assay. Quality of sperm chromatin condensation was assessed by toluidine blue, aniline blue and chromomycin A3 staining. We can conclude that the impact of elevated BMI on the parameters investigated (basic semen parameters, chromatin integrity and chromatin condensation) was not proven in this study. On the other hand, ejaculate quality appeared to be affected by ageing. The impact was reflected by chromatin integrity, which is a factor that can substantially affect fertility in men, rather than by basic sperm parameters.
肥胖会对人体健康产生不良影响，包括生育能力。虽然肥胖会扰乱女性机体的激素谱，并与生育能力丧失有关，但对于男性肥胖对生育能力的影响知之甚少。本研究分析了 153 名供体的精子样本。这些男性是从不孕诊所就诊的夫妇中挑选出来的，他们已经尝试怀孕 12 个月或更长时间，但没有成功。记录了研究对象的年龄，并计算了他们的体重指数（BMI）。所有精液样本均评估了体积、浓度、活力和形态。通过精子染色质结构分析评估精子染色质完整性。通过甲苯胺蓝、苯胺蓝和 Chromomycin A3 染色评估精子染色质凝聚的质量。我们可以得出结论，在这项研究中，没有证明升高的 BMI 对所研究的参数（基本精液参数、染色质完整性和染色质凝聚）有影响。另一方面，精液质量似乎受到年龄的影响。这种影响反映在染色质完整性上，这是一个可以极大地影响男性生育能力的因素，而不是基本的精子参数。
