高脂饮食喂养的 PANDER KO 小鼠表现为葡萄糖不耐受，但对禁食性高血糖和高胰岛素血症有抵抗。
PANDER KO mice on high-fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia.
机构信息
Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, United States.
出版信息
FEBS Lett. 2011 May 6;585(9):1345-9. doi: 10.1016/j.febslet.2011.04.005. Epub 2011 Apr 7.
Abstract
The recent creation of the PANDER (pancreatic-derived factor) knockout (PANKO) and acute mouse models have revealed a biological function in the regulation of glycemic levels via promotion of hepatic glucose production (HGP) and pancreatic β-cell insulin secretion. Therefore, we hypothesized that the absence of PANDER may afford some degree of protection from high-fat diet (HFD) induced fasting hyperglycemia. On HFD, fasting glycemic levels were significantly lower in the PANKO mice. Also, fasting insulin levels and the in vivo insulin response following glucose injection were inhibited in PANKO mice. The lowered fasting glycemic levels are attributed to decreased HGP due to the absence of PANDER. Overall, our findings further indicate PANDER impacts glycemic levels and may represent a potential but complicated therapeutic target.
摘要
最近创建的 PANDER（胰腺衍生因子）敲除（PANKO）和急性小鼠模型揭示了其在通过促进肝葡萄糖生成（HGP）和胰腺β细胞胰岛素分泌来调节血糖水平方面的生物学功能。因此，我们假设 PANDER 的缺失可能在一定程度上提供了对高脂肪饮食（HFD）诱导的空腹高血糖的保护作用。在 HFD 喂养下，PANKO 小鼠的空腹血糖水平显著降低。此外，PANKO 小鼠的空腹胰岛素水平和葡萄糖注射后的体内胰岛素反应受到抑制。由于缺乏 PANDER，空腹血糖水平降低归因于 HGP 的减少。总的来说，我们的研究结果进一步表明 PANDER 影响血糖水平，并可能代表一个潜在但复杂的治疗靶点。
相似文献
1
PANDER KO mice on high-fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia.高脂饮食喂养的 PANDER KO 小鼠表现为葡萄糖不耐受，但对禁食性高血糖和高胰岛素血症有抵抗。
FEBS Lett. 2011 May 6;585(9):1345-9. doi: 10.1016/j.febslet.2011.04.005. Epub 2011 Apr 7.
2
Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice.胰腺衍生因子（PANDER）基因敲除的C57BL/6小鼠葡萄糖耐量增强。
Dis Model Mech. 2014 Nov;7(11):1307-15. doi: 10.1242/dmm.016402. Epub 2014 Sep 12.
3
Effect of chronic p,p'-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H mice.慢性 p,p'-二氯二苯二氯乙烯 (DDE) 暴露对雄性 C57BL/6H 小鼠高脂饮食诱导的葡萄糖和脂质代谢改变的影响。
Toxicology. 2015 Feb 3;328:112-22. doi: 10.1016/j.tox.2014.12.017. Epub 2014 Dec 23.
4
Liver-specific overexpression of pancreatic-derived factor (PANDER) induces fasting hyperglycemia in mice.肝特异性过表达胰腺衍生因子（PANDER）可诱导小鼠空腹高血糖。
Endocrinology. 2010 Nov;151(11):5174-84. doi: 10.1210/en.2010-0379. Epub 2010 Sep 15.
5
PANDER transgenic mice display fasting hyperglycemia and hepatic insulin resistance.PANDER 转基因小鼠表现出空腹高血糖和肝胰岛素抵抗。
J Endocrinol. 2014 Jan 27;220(3):219-31. doi: 10.1530/JOE-13-0338. Print 2014 Mar.
6
Targeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell function.靶向敲除胰腺衍生因子（PANDER，FAM3B）可损害胰岛β细胞功能。
Diabetes. 2010 Sep;59(9):2209-18. doi: 10.2337/db09-1552. Epub 2010 Jun 21.
7
Metformin reduces body weight gain and improves glucose intolerance in high-fat diet-fed C57BL/6J mice.二甲双胍可降低高脂饮食喂养的 C57BL/6J 小鼠的体重增加并改善葡萄糖不耐受。
Biol Pharm Bull. 2010;33(6):963-70. doi: 10.1248/bpb.33.963.
8
Taurine supplementation prevents morpho-physiological alterations in high-fat diet mice pancreatic β-cells.牛磺酸补充可预防高脂肪饮食诱导的小鼠胰岛β细胞形态和生理改变。
Amino Acids. 2012 Oct;43(4):1791-801. doi: 10.1007/s00726-012-1263-5. Epub 2012 Mar 15.
9
Reversal of glucose intolerance by by pioglitazone in high fat diet-fed rats.吡格列酮对高脂饮食喂养大鼠葡萄糖耐量异常的逆转作用
Methods Find Exp Clin Pharmacol. 2004 Jun;26(5):327-33. doi: 10.1358/mf.2004.26.5.831322.
10
Switching from high-fat to low-fat diet normalizes glucose metabolism and improves glucose-stimulated insulin secretion and insulin sensitivity but not body weight in C57BL/6J mice.从高脂肪饮食转换为低脂肪饮食可使葡萄糖代谢正常化，并改善葡萄糖刺激的胰岛素分泌和胰岛素敏感性，但对 C57BL/6J 小鼠的体重没有影响。
Pancreas. 2012 Mar;41(2):253-7. doi: 10.1097/MPA.0b013e3182243107.
引用本文的文献
1
FAM3B (PANDER) functions as a co-activator of FOXO1 to promote gluconeogenesis in hepatocytes.FAM3B（PANDER）作为 FOXO1 的共激活因子，在肝细胞中促进糖异生。
J Cell Mol Med. 2019 Mar;23(3):1746-1758. doi: 10.1111/jcmm.14073. Epub 2018 Nov 28.
2
Circulating PANDER concentration is associated with increased HbA1c and fasting blood glucose in Type 2 diabetic subjects.在2型糖尿病患者中，循环中的PANDER浓度与糖化血红蛋白（HbA1c）升高及空腹血糖升高相关。
J Clin Transl Endocrinol. 2018 Feb 23;11:26-30. doi: 10.1016/j.jcte.2018.02.003. eCollection 2018 Mar.
3
FAM3B mediates high glucose-induced vascular smooth muscle cell proliferation and migration via inhibition of miR-322-5p.FAM3B 通过抑制 miR-322-5p 介导高糖诱导的血管平滑肌细胞增殖和迁移。
Sci Rep. 2017 May 23;7(1):2298. doi: 10.1038/s41598-017-02683-3.
4
Elevated circulating level of a cytokine, pancreatic-derived factor, is associated with metabolic syndrome components in a Chinese population.细胞因子胰腺衍生因子的循环水平升高与中国人群的代谢综合征组分相关。
J Diabetes Investig. 2016 Jul;7(4):581-6. doi: 10.1111/jdi.12437. Epub 2015 Nov 14.
5
Altered Body Weight Regulation in CK1ε Null and tau Mutant Mice on Regular Chow and High Fat Diets.正常饮食和高脂饮食条件下CK1ε基因敲除及tau基因突变小鼠的体重调节变化
Genet Res Int. 2016;2016:4973242. doi: 10.1155/2016/4973242. Epub 2016 Apr 6.
6
Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice.胰腺衍生因子（PANDER）基因敲除的C57BL/6小鼠葡萄糖耐量增强。
Dis Model Mech. 2014 Nov;7(11):1307-15. doi: 10.1242/dmm.016402. Epub 2014 Sep 12.
7
PANcreatic-DERived factor: novel hormone PANDERing to glucose regulation.胰腺衍生因子：调节血糖的新型激素 PANDER。
FEBS Lett. 2011 Jul 21;585(14):2137-43. doi: 10.1016/j.febslet.2011.05.059. Epub 2011 Jun 12.
本文引用的文献
1
Liver-specific overexpression of pancreatic-derived factor (PANDER) induces fasting hyperglycemia in mice.肝特异性过表达胰腺衍生因子（PANDER）可诱导小鼠空腹高血糖。
Endocrinology. 2010 Nov;151(11):5174-84. doi: 10.1210/en.2010-0379. Epub 2010 Sep 15.
2
Characterization of the expression, localization, and secretion of PANDER in alpha-cells.鉴定α细胞中 PANDER 的表达、定位和分泌情况。
Mol Cell Endocrinol. 2010 Aug 30;325(1-2):36-45. doi: 10.1016/j.mce.2010.05.008.
3
Targeted disruption of pancreatic-derived factor (PANDER, FAM3B) impairs pancreatic beta-cell function.靶向敲除胰腺衍生因子（PANDER，FAM3B）可损害胰岛β细胞功能。
Diabetes. 2010 Sep;59(9):2209-18. doi: 10.2337/db09-1552. Epub 2010 Jun 21.
4
PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells.PANDER与肝细胞膜结合并抑制HepG2细胞中的胰岛素信号传导。
FEBS Lett. 2009 Sep 17;583(18):3009-15. doi: 10.1016/j.febslet.2009.08.008. Epub 2009 Aug 14.
5
Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.胰高血糖素受体基因敲除小鼠表现出胰岛素敏感性增加和β细胞功能受损。
Diabetes. 2006 Dec;55(12):3463-9. doi: 10.2337/db06-0307.
6
Inflammation and insulin resistance.炎症与胰岛素抵抗
J Clin Invest. 2006 Jul;116(7):1793-801. doi: 10.1172/JCI29069.
7
Pathogenesis of type 2 diabetes mellitus.2型糖尿病的发病机制。
Arch Med Res. 2005 May-Jun;36(3):197-209. doi: 10.1016/j.arcmed.2005.01.003.
8
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.MODY1基因HNF-4α调节参与胰岛素分泌的特定基因。
J Clin Invest. 2005 Apr;115(4):1006-15. doi: 10.1172/JCI22365. Epub 2005 Mar 3.
9
Pancreatic-derived factor (FAM3B), a novel islet cytokine, induces apoptosis of insulin-secreting beta-cells.胰腺衍生因子（FAM3B），一种新型胰岛细胞因子，可诱导胰岛素分泌β细胞凋亡。
Diabetes. 2003 Sep;52(9):2296-303. doi: 10.2337/diabetes.52.9.2296.
10
Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production.胰岛素信号传导是胰岛素对肝脏葡萄糖生成直接和间接作用所必需的。
J Clin Invest. 2003 Feb;111(4):463-8. doi: 10.1172/JCI16426.
Zotero 插件