胰腺衍生因子：调节血糖的新型激素 PANDER。
PANcreatic-DERived factor: novel hormone PANDERing to glucose regulation.
机构信息
University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA 19104, United States.
出版信息
FEBS Lett. 2011 Jul 21;585(14):2137-43. doi: 10.1016/j.febslet.2011.05.059. Epub 2011 Jun 12.
Abstract
PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-cells. Initial characterization of PANDER revealed a potential role in pancreatic islet apoptosis. However, recent animal models have indicated PANDER functions as a hormone by regulating glucose levels via interaction with both the liver and the endocrine pancreas. An understanding of the function of PANDER can further the insight into the mechanisms of glucose regulation and potentially provide additional therapeutic targets for the treatment of diabetes. This review details the supporting data demonstrating PANDER has a biological function in glycemic regulation.
摘要
胰腺衍生因子（PANDER，FAM3B）是细胞因子家族 FAM3 家族的成员，该家族最初于 2002 年被描述。PANDER 的表达主要定位于内分泌胰腺，由胰腺α和β细胞分泌。PANDER 的初步特征表明其在胰岛细胞凋亡中具有潜在作用。然而，最近的动物模型表明 PANDER 通过与肝脏和内分泌胰腺相互作用来调节葡萄糖水平，从而发挥激素的功能。了解 PANDER 的功能可以进一步深入了解葡萄糖调节的机制，并为糖尿病的治疗提供额外的治疗靶点。本文综述了支持 PANDER 在血糖调节中具有生物学功能的相关数据。
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