Waite Oliver, Yaffy Dylan, Kathrani Aarti
Department of Clinical Science and Services, Royal Veterinary College, University of London, North Mymms, Hertfordshire, UK.
Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, North Mymms, Hertfordshire, UK.
JFMS Open Rep. 2023 Jul 4;9(2):20551169231178442. doi: 10.1177/20551169231178442. eCollection 2023 Jul-Dec.
A 7.5-year-old neutered male Oriental Shorthair cat presented with an 8-month history of haematochezia, mucoid diarrhoea, tenesmus and vocalisation after a 4-year history of small bowel diarrhoea. Transabdominal ultrasonography confirmed diffuse colonic wall thickening and extensive ulceration and erythema after colonoscopy. Colonic histopathology confirmed periodic acid-Schiff positive macrophages, consistent with granulomatous colitis; was cultured from colonic biopsy specimens. Fluorescent in situ hybridisation (FISH) identified intracellular , and an 8-week oral course of marbofloxacin, a hydrolysed protein diet and a 5-day course of fenbendazole yielded a transient partial clinical remission of the colitis signs. A reported resolution in the small bowel signs was also reported. Colonoscopy was repeated 5 months later due to the recurrence of colitis signs. Histopathology was not consistent with granulomatous colitis supporting a complete remission; however, a chronic inflammatory enteropathy was confirmed with moderate lymphoplasmacytic, neutrophilic and eosinophilic colitis without a histiocytic component. was again cultured from colonic biopsies with sensitivity to fluoroquinolones; FISH was positive for intracellular . Clinical signs persisted despite a 2-week course of oral marbofloxacin.
-associated granulomatous colitis is rare in cats. Colonic biopsy specimen culture is important to guide appropriate antibiotic therapy. Repeat histopathology, culture and FISH have not been previously reported after treatment of a cat with -associated granulomatous colitis. Persistent clinical signs after treatment with oral marbofloxacin alongside a confirmed complete histologic remission support the presence of a concurrent chronic inflammatory enteropathy and pathology for the cat's ongoing colitis.
一只7.5岁已绝育的雄性东方短毛猫，在出现小肠腹泻4年后，出现便血、黏液性腹泻、里急后重和鸣叫8个月。经腹超声检查证实结肠壁弥漫性增厚，结肠镜检查后发现广泛溃疡和红斑。结肠组织病理学证实高碘酸-希夫染色阳性巨噬细胞，符合肉芽肿性结肠炎；从结肠活检标本中培养出[具体病菌名称未给出]。荧光原位杂交（FISH）鉴定出细胞内[具体病菌名称未给出]，口服8周的马波沙星、水解蛋白饮食和5天的芬苯达唑疗程使结肠炎症状暂时部分缓解。还报告了小肠症状的缓解。由于结肠炎症状复发，5个月后再次进行结肠镜检查。组织病理学与肉芽肿性结肠炎不一致，支持完全缓解；然而，确诊为慢性炎症性肠病，伴有中度淋巴细胞性、嗜中性粒细胞性和嗜酸性粒细胞性结肠炎，无组织细胞成分。从结肠活检中再次培养出[具体病菌名称未给出]，对氟喹诺酮类敏感；FISH检测细胞内[具体病菌名称未给出]呈阳性。尽管口服马波沙星2周，临床症状仍持续存在。
与[具体病菌名称未给出]相关的肉芽肿性结肠炎在猫中罕见。结肠活检标本培养对于指导适当的抗生素治疗很重要。此前尚未报道过用与[具体病菌名称未给出]相关的肉芽肿性结肠炎治疗猫后进行重复组织病理学、培养和FISH检查。口服马波沙星治疗后临床症状持续存在，同时组织学完全缓解，支持存在并发的慢性炎症性肠病以及该猫持续结肠炎的病理学表现。
