血液单核细胞和血小板标志物与颈动脉特征的关联：社区动脉粥样硬化风险的颈动脉 MRI 研究。
Association of blood monocyte and platelet markers with carotid artery characteristics: the atherosclerosis risk in communities carotid MRI study.
机构信息
Center for Translational Injury Research, Department of Surgery, University of Texas Health Science Center at Houston, 77030, USA.
出版信息
Cerebrovasc Dis. 2011;31(6):552-8. doi: 10.1159/000324389. Epub 2011 Apr 12.
Abstract
BACKGROUND
Atherosclerosis is characterized by infiltration of inflammatory cells from circulating blood. Blood cell activation could play an important role in plaque formation.
METHODS
We analyzed the relationship between blood cellular markers and quantitative measures of carotid wall components in 1,546 participants from the ARIC (Atherosclerosis Risk in Communities) Carotid MRI Study. Carotid imaging was performed using a gadolinium contrast-enhanced MRI and cellular phenotyping by flow cytometry.
RESULTS
Monocyte Toll-like receptor (TLR)-2 is associated with larger plaques, while CD14, myeloperoxidase, and TLR-4 associate with smaller. Platelet CD40L is associated with smaller plaques and thinner caps, while P-selectin is associated with smaller core size.
CONCLUSIONS
Blood cell activation is significantly associated with atherosclerotic changes of the carotid wall.
摘要
背景
动脉粥样硬化的特征是循环血液中的炎症细胞浸润。血细胞的激活可能在斑块形成中起重要作用。
方法
我们分析了来自 ARIC（社区动脉粥样硬化风险）颈动脉 MRI 研究的 1546 名参与者的血液细胞标志物与颈动脉壁成分定量测量之间的关系。颈动脉成像采用钆增强 MRI 进行，细胞表型分析采用流式细胞术。
结果
单核细胞 Toll 样受体（TLR）-2 与较大的斑块相关，而 CD14、髓过氧化物酶和 TLR-4 则与较小的斑块相关。血小板 CD40L 与较小的斑块和较薄的帽相关，而 P-选择素与较小的核心大小相关。
结论
血细胞的激活与颈动脉壁的粥样硬化变化显著相关。
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