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Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS.激活血脑屏障中的蛋白激酶 C-β1 可逆转二噁英诱导的 P-糖蛋白活性，并恢复药物向中枢神经系统的递送。
J Cereb Blood Flow Metab. 2011 Jun;31(6):1371-5. doi: 10.1038/jcbfm.2011.44. Epub 2011 Apr 13.
2
Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.PKC 同工型β（I）在血脑屏障的激活可迅速降低 P-糖蛋白的活性，从而增强药物向脑内的递送。
J Cereb Blood Flow Metab. 2010 Jul;30(7):1373-83. doi: 10.1038/jcbfm.2010.21. Epub 2010 Mar 3.
3
Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.血管内皮生长因子对血脑屏障 P 糖蛋白转运活性的快速、可逆调节。
J Neurosci. 2010 Jan 27;30(4):1417-25. doi: 10.1523/JNEUROSCI.5103-09.2010.
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Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain.靶向血脑屏障鞘脂信号可降低基础 P-糖蛋白活性并改善药物向脑内的递送。
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15930-5. doi: 10.1073/pnas.1203534109. Epub 2012 Sep 4.
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Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.质子偶联叶酸转运体（PCFT）突变小鼠血脑屏障 P-糖蛋白的功能调节。
FASEB J. 2013 Mar;27(3):1167-75. doi: 10.1096/fj.12-218495. Epub 2012 Dec 4.
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Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.芳基烃受体介导的血脑屏障中外源化学物外排转运蛋白的 ATP 驱动上调。
FASEB J. 2011 Feb;25(2):644-52. doi: 10.1096/fj.10-169227. Epub 2010 Nov 3.
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Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay.利用一种新型原位蛋白水解保护试验证明，通过转运蛋白内化作用，血脑屏障P-糖蛋白活性迅速丧失。
J Cereb Blood Flow Metab. 2010 Sep;30(9):1593-7. doi: 10.1038/jcbfm.2010.117. Epub 2010 Jul 14.
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Impact of Zn on ABC Transporter Function in Intact Isolated Rat Brain Microvessels, Human Brain Capillary Endothelial Cells, and in Rat in Vivo.锌对完整离体大鼠脑微血管、人脑毛细血管内皮细胞和大鼠体内 ABC 转运蛋白功能的影响。
Mol Pharm. 2019 Jan 7;16(1):305-317. doi: 10.1021/acs.molpharmaceut.8b00987. Epub 2018 Nov 29.
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Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism.对乙酰氨基酚通过组成型雄烷受体依赖性机制调节血脑屏障的 P-糖蛋白功能表达。
Mol Pharmacol. 2013 Nov;84(5):774-86. doi: 10.1124/mol.113.086298. Epub 2013 Sep 9.
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A novel positron emission tomography imaging protocol identifies seizure-induced regional overactivity of P-glycoprotein at the blood-brain barrier.一种新的正电子发射断层扫描成像方案可识别血脑屏障 P-糖蛋白诱导的癫痫发作相关区域过度活跃。
J Neurosci. 2011 Jun 15;31(24):8803-11. doi: 10.1523/JNEUROSCI.6616-10.2011.
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The tryptophan metabolic pathway of the microbiome and host cells in health and disease.微生物组和宿主细胞在健康和疾病中的色氨酸代谢途径。
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2
Study of fingolimod, nitric oxide inhibitor, and P-glycoprotein inhibitor in modulating the P-glycoprotein expression via an endothelin-sphingolipid pathway in an animal model of pharmacoresistant epilepsy.研究替比司特、一氧化氮抑制剂和 P-糖蛋白抑制剂通过内皮素-鞘脂途径调节耐药性癫痫动物模型中 P-糖蛋白表达。
Indian J Pharmacol. 2023 Sep-Oct;55(5):307-314. doi: 10.4103/ijp.ijp_100_23.
3
Simulated Microgravity Alters P-Glycoprotein Efflux Function and Expression via the Wnt/β-Catenin Signaling Pathway in Rat Intestine and Brain.模拟微重力通过 Wnt/β-连环蛋白信号通路改变大鼠肠道和脑中 P-糖蛋白的外排功能和表达。
Int J Mol Sci. 2023 Mar 12;24(6):5438. doi: 10.3390/ijms24065438.
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Host-microbiota interactions: The aryl hydrocarbon receptor in the acute and chronic phases of cerebral ischemia.宿主-微生物群相互作用：脑缺血急慢性期中的芳香烃受体。
Front Immunol. 2022 Aug 12;13:967300. doi: 10.3389/fimmu.2022.967300. eCollection 2022.
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David S. Miller: Scientist, Mentor, Friend-a tribute and thank you.大卫·S·米勒：科学家、导师、朋友——致敬与感谢
Fluids Barriers CNS. 2020 Sep 14;17(1):56. doi: 10.1186/s12987-020-00220-5.
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Enteric Microbiota⁻Gut⁻Brain Axis from the Perspective of Nuclear Receptors.从核受体角度看肠微生物群-肠道-脑轴
Int J Mol Sci. 2018 Jul 28;19(8):2210. doi: 10.3390/ijms19082210.
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Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling.对甲酚硫酸盐通过芳烃受体信号上调肝 P-糖蛋白的表达和活性。
J Am Soc Nephrol. 2018 Mar;29(3):906-918. doi: 10.1681/ASN.2017030361. Epub 2017 Dec 8.
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Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system.宿主-微生物组相互作用：芳烃受体与中枢神经系统
J Mol Med (Berl). 2017 Jan;95(1):29-39. doi: 10.1007/s00109-016-1486-0. Epub 2016 Nov 17.
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Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.健康与神经疾病状态下血脑屏障处ABC外排转运体的调控
Brain Res. 2015 Dec 2;1628(Pt B):298-316. doi: 10.1016/j.brainres.2015.07.005. Epub 2015 Jul 15.
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Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status.恩杂鲁胺可独立于对蛋白激酶C信号传导和细胞p53状态的影响，抑制ABCB1介导的药物外排。
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本文引用的文献
1
Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.芳基烃受体介导的血脑屏障中外源化学物外排转运蛋白的 ATP 驱动上调。
FASEB J. 2011 Feb;25(2):644-52. doi: 10.1096/fj.10-169227. Epub 2010 Nov 3.
2
Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.血脑屏障上的 ATP 驱动型外排转运体被组成型雄烷受体调控。
Mol Pharmacol. 2010 Sep;78(3):376-83. doi: 10.1124/mol.110.063685. Epub 2010 Jun 14.
3
Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier.血脑屏障上 P-糖蛋白和其他 ABC 型药物转运体的调控。
Trends Pharmacol Sci. 2010 Jun;31(6):246-54. doi: 10.1016/j.tips.2010.03.003. Epub 2010 Apr 24.
4
Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.PKC 同工型β（I）在血脑屏障的激活可迅速降低 P-糖蛋白的活性，从而增强药物向脑内的递送。
J Cereb Blood Flow Metab. 2010 Jul;30(7):1373-83. doi: 10.1038/jcbfm.2010.21. Epub 2010 Mar 3.
5
Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.血管内皮生长因子对血脑屏障 P 糖蛋白转运活性的快速、可逆调节。
J Neurosci. 2010 Jan 27;30(4):1417-25. doi: 10.1523/JNEUROSCI.5103-09.2010.
6
An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology.人类和生态流行病学所记录的二噁英及二噁英类化合物对脊椎动物影响的概述。
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Oct;27(4):197-211. doi: 10.1080/10590500903310047.
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Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier.核受体对血脑屏障处外排转运体Mrp2和II相代谢酶GSTpi的协同调控
J Cereb Blood Flow Metab. 2008 Jun;28(6):1222-34. doi: 10.1038/jcbfm.2008.16. Epub 2008 Mar 19.
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Drug targeting to the brain.药物靶向大脑。
Pharm Res. 2007 Sep;24(9):1733-44. doi: 10.1007/s11095-007-9324-2. Epub 2007 Jun 7.
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Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases.大鼠实验性糖尿病中血脑屏障通透性增加及紧密连接改变：高血糖和基质金属蛋白酶的作用
Diabetologia. 2007 Jan;50(1):202-11. doi: 10.1007/s00125-006-0485-z. Epub 2006 Dec 2.
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Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide.肿瘤坏死因子-α和脂多糖对血脑屏障处P-糖蛋白介导转运的快速调节作用
Mol Pharmacol. 2006 Feb;69(2):462-70. doi: 10.1124/mol.105.017954. Epub 2005 Nov 8.
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