Busaracome Ploysyne, Wattanakrai Penpun, Rajatanavin Natta
Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Case Rep Dermatol. 2011 Feb 25;3(1):49-54. doi: 10.1159/000325068.
Chronic actinic dermatitis is a chronic photosensitivity disorder characterized by severe eczematous lesions on sun-exposed skin areas. We report a case of chronic actinic dermatitis presenting with leonine facies and secondary adrenal insufficiency, which was successfully treated with topical tacrolimus. The facial lesions dramatically improved after sun avoidance and topical tacrolimus application. After almost 20 years of oral corticosteroid therapy complicated with secondary adrenal insufficiency, we were able to switch treatment from systemic corticosteroids to topical tacrolimus to control the patient's symptoms.
慢性光化性皮炎是一种慢性光敏性疾病，其特征为暴露于阳光下的皮肤区域出现严重的湿疹样皮损。我们报告一例以狮面和继发性肾上腺功能不全为表现的慢性光化性皮炎病例，该病例通过外用他克莫司成功治愈。避免日晒并外用他克莫司后，面部皮损显著改善。在经历了近20年的口服糖皮质激素治疗并伴有继发性肾上腺功能不全后，我们成功地将治疗从全身用糖皮质激素转换为外用他克莫司来控制患者症状。
