Sosnowski C
St. Elizabeth Hospital Medical Center, Youngstown, Ohio 44501-1790.
J Neurosci Nurs. 1990 Dec;22(6):382-4. doi: 10.1097/01376517-199012000-00009.
Many patients survive aneurysmal SAH with minimal neurological deficits, but are at risk for developing further neurological insult from ischemia resulting from cerebral vasospasm. Nimodipine has proven to be effective in preventing this complication in a majority of patients studied, with hypotension the most severe adverse effect. Nimodipine alone, or in combination with other methods of therapy, may significantly improve the neurological outcome in this select patient population.
许多动脉瘤性蛛网膜下腔出血患者存活下来，神经功能缺损轻微，但有因脑血管痉挛导致的缺血而发生进一步神经损伤的风险。在大多数研究的患者中，尼莫地平已被证明可有效预防这种并发症，低血压是最严重的不良反应。单独使用尼莫地平或与其他治疗方法联合使用，可能会显著改善这一特定患者群体的神经功能结局。
