University of Hawaii, Hawaii, USA.
Qual Life Res. 2011 Dec;20(10):1589-93. doi: 10.1007/s11136-011-9910-y. Epub 2011 Apr 13.
To assess whether the measurement error, and recall bias can reach magnitudes comparable to minimally important difference (MID) in symptoms scores used in chronic venous disease-specific quality of life QOL instruments, such as Specific Quality of Life & Outcomes Response-Venous (SQOR-V) questionnaire.
Prospective non-randomized study of 150 patients with primary chronic venous disease. SQOR-V questionnaire was administered prior to clinical visit (in 32 patients twice), and 1 month post-treatment. Patients were asked to recall their symptoms 12 months later. Measurement error (SEM) was calculated from repeated baseline measurements. MID was derived from change in the symptom score (SS) part of the SQOR-V questionnaire at 1 month. Recall bias was calculated from 12-month recall data.
SEM was 1.91, the recall bias was -3.16 (95% CI from -4.08 to -2.24), and the MID was 3.7. In the treatment group the recall bias was negative (recall more severe symptoms than they actually were at the baseline), patients in the observation group had positive recall bias. SS change moderately correlated with transition rating index (Spearman rank-order correlation 0.526, P < 0.0001), and strongly correlated with the baseline value (Pearson r = 0.84).
The measurement error of patient-reported symptoms scores included in disease-specific QOL instruments is small, but recall bias is close in magnitude to MID.
评估慢性静脉疾病特定生活质量（QOL）工具中症状评分的测量误差和回忆偏倚是否可达到与最小有意义差异（MID）相当的程度，例如特定 QOL 和结局反应-静脉（SQOR-V）问卷。
对 150 例原发性慢性静脉疾病患者进行前瞻性非随机研究。在临床就诊前（32 例患者两次）和治疗后 1 个月时，使用 SQOR-V 问卷进行评估。要求患者在 12 个月后回忆他们的症状。从重复的基线测量中计算测量误差（SEM）。MID 源自 SQOR-V 问卷中症状评分（SS）部分在 1 个月时的变化。从 12 个月的回忆数据中计算回忆偏倚。
SEM 为 1.91，回忆偏倚为-3.16（95%置信区间为-4.08 至-2.24），MID 为 3.7。在治疗组中，回忆偏倚为负值（回忆起比基线时更严重的症状），观察组患者的回忆偏倚为正值。SS 变化与过渡评分指数中度相关（Spearman 等级相关 0.526，P < 0.0001），与基线值高度相关（Pearson r = 0.84）。
包含在疾病特异性 QOL 工具中的患者报告症状评分的测量误差较小，但回忆偏倚与 MID 相当。
