Genotoxicity investigation of ELF-magnetic fields in Salmonella typhimurium with the sensitive SOS-based VITOTOX test.

作者信息

Verschaeve Luc, Anthonissen Roel, Grudniewska Magda, Wudarski Jakub, Gevaert Lieven, Maes Annemarie

机构信息

Laboratory of Toxicology, O.D. Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium.

出版信息

Bioelectromagnetics. 2011 Oct;32(7):580-4. doi: 10.1002/bem.20672. Epub 2011 Apr 12.

We performed a genotoxicity investigation of extremely low-frequency (ELF) magnetic fields (MFs, 50 Hz, 100 and 500 µT, 1 and 2 h exposure) alone and in combination with known chemical mutagens using the VITOTOX test. This test is a very sensitive reporter assay of Salmonella typhimurium bacteria based on the SOS response. Our study showed that ELF-MFs do not induce SOS-based mutagenicity in S. typhimurium bacteria and do not show any synergetic effect when combined with chemical mutagens.