猪窦卵泡中的明胶酶（MMP2 和 MMP9）。
Gelatinases (MMP2 and MMP9) in swine antral follicle.
机构信息
Dipartimento di Produzioni Animali, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti - Sezione di Fisiologia Veterinaria, Università degli Studi di Parma, Italy.
出版信息
Biofactors. 2011 Mar-Apr;37(2):117-20. doi: 10.1002/biof.153.
Follicular growth is allowed by extracellular matrix remodeling and vascular network development. Since matrix metalloproteinases (MMPs) play a crucial role in both of these processes, the aim of the present study was to evaluate the expression of gelatinases MMP2 and MMP9 in swine ovarian follicle (theca and granulosa compartments) during its development. Moreover, we measured gelatinase activities into follicular fluids (FF). Our data demonstrate for the first time that MMP2 and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers; moreover we show that the expression of both gelatinases increases in theca while decreases in granulosa during follicle growth. Additionally, MMP2 activity has been detected in FF. The spatial pattern of expression of gelatinases in swine follicle suggests a differential role during physiological ovarian events.
卵泡的生长允许细胞外基质重塑和血管网络的发展。由于基质金属蛋白酶（MMPs）在这两个过程中都起着至关重要的作用，本研究的目的是评估明胶酶 MMP2 和 MMP9 在猪卵巢卵泡（膜层和颗粒层）发育过程中的表达。此外，我们还测量了卵泡液（FF）中的明胶酶活性。我们的数据首次表明，MMP2 和 MMP9 在猪卵巢卵泡的膜层和颗粒层中均有表达；此外，我们还表明，两种明胶酶的表达在卵泡生长过程中在膜层中增加，而在颗粒层中减少。此外，在 FF 中检测到 MMP2 活性。明胶酶在猪卵泡中的表达模式表明，它们在生理卵巢事件中具有不同的作用。
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