Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1730-7. doi: 10.1016/j.ijrobp.2011.02.008. Epub 2011 Apr 12.
To update the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases by surveying international experts regarding previous uncertainties within the 2002 consensus, changes that may be necessary based on practice pattern changes and research findings since that time.
A two-phase survey was used to determine revisions and new additions to the 2002 consensus. A total of 49 experts from the American Society for Radiation Oncology, the European Society for Therapeutic Radiology and Oncology, the Faculty of Radiation Oncology of the Royal Australian and New Zealand College of Radiologists, and the Canadian Association of Radiation Oncology who are directly involved in the care of patients with bone metastases participated in this survey.
Consensus was established in areas involving response definitions, eligibility criteria for future trials, reirradiation, changes in systemic therapy, radiation techniques, parameters at follow-up, and timing of assessments.
An outline for trials in bone metastases was updated based on survey and consensus. Investigators leading trials in bone metastases are encouraged to adopt the revised guideline to promote consistent reporting. Areas for future research were identified. It is intended for the consensus to be re-examined in the future on a regular basis.
通过调查国际专家，了解 2002 年共识中存在的先前不确定性，以及自那时以来基于实践模式变化和研究发现可能需要做出的改变，更新骨转移姑息性放疗终点的国际共识，以便未来在临床试验中使用。
采用两阶段调查的方法，确定 2002 年共识的修订和新增内容。共有来自美国放射肿瘤学会、欧洲肿瘤放射治疗学会、澳大利亚和新西兰皇家放射肿瘤学院放射肿瘤学学院以及加拿大放射肿瘤学会的 49 名专家参与了这项调查，他们直接参与了骨转移患者的治疗。
在反应定义、未来试验的入选标准、再放疗、系统治疗变化、放射技术、随访参数和评估时间等方面达成了共识。
根据调查和共识，更新了骨转移试验的方案。鼓励进行骨转移试验的研究人员采用修订后的指南，以促进一致的报告。确定了未来研究的领域。旨在定期对共识进行重新审查。
