Department of Chemistry, Duke University, Durham, NC 27708, USA.
Curr Opin Chem Biol. 2011 Jun;15(3):350-4. doi: 10.1016/j.cbpa.2011.03.004. Epub 2011 Apr 12.
Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules. Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of biomolecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development.
通过自然选择过程，天然产物具有独特而广泛的化学多样性，并为与生物大分子的最佳相互作用而进化。由于其多样性、靶标亲和力和特异性，天然产物已显示出作为生物分子功能调节剂的巨大潜力，是药物发现的重要来源，并为组合文库的发展提供了设计原则。
