United States Department of Agriculture, ARS/SPARC, College Station, TX 77845, USA.
Poult Sci. 2011 May;90(5):1014-9. doi: 10.3382/ps.2010-01246.
In previous studies we characterized the innate immune response of 2 parental broiler lines (A and B) and compared their resistance against Salmonella, Enterococcus, and Campylobacter challenges. In all cases, line A was more responsive and more resistant than line B. In the present study, we sought to determine whether this trend was also observed following challenge with the protozoan parasite Eimeria tenella. In 3 separate experiments, 14-d-old chickens from lines A and B were challenged orally with 15 to 50 × 10(3) E. tenella oocysts. Birds were killed 6 d postchallenge and the ceca was removed and scored for lesions and weight gain compared with noninfected controls. Line A birds were more resistant to intestinal pathology as demonstrated by lower lesion scores compared with line B birds. As might be expected, the lower lesion scores in line A chickens were often accompanied by higher weight gain compared with line B chickens, thus reducing potential revenue loss associated with low carcass weights often observed with coccidia-infected birds. The results from this study showed that in addition to having enhanced resistance against bacterial infections, line A chickens were also more resistant to coccidial infections compared with line B birds. Taken together with all of our earlier studies using these lines of birds, an efficient innate immune response protects against a broad range of foodborne and poultry pathogens, including costly coccidial infections.
在之前的研究中，我们对 2 个父母代肉鸡品系（A 和 B）的固有免疫反应进行了表征，并比较了它们对沙门氏菌、肠球菌和弯曲杆菌挑战的抵抗力。在所有情况下，A 系比 B 系更敏感和更具抗性。在本研究中，我们试图确定在受到原生动物寄生虫柔嫩艾美耳球虫（Eimeria tenella）的挑战后，是否也观察到这种趋势。在 3 个单独的实验中，来自 A 系和 B 系的 14 日龄鸡用 15 到 50×10(3)个柔嫩艾美耳球虫卵囊经口挑战。在感染后 6 天，处死鸡并取出盲肠，与未感染对照相比，对病变和体重增加进行评分。与 B 系鸡相比，A 系鸡对肠道病理更有抵抗力，表现为病变评分较低。正如预期的那样，A 系鸡的较低病变评分通常伴随着比 B 系鸡更高的体重增加，从而降低了与球虫感染鸡常见的低胴体重量相关的潜在收入损失。这项研究的结果表明，除了对细菌感染具有增强的抵抗力外，与 B 系鸡相比，A 系鸡对球虫感染也更具抵抗力。结合我们使用这些鸡系进行的所有早期研究，有效的固有免疫反应可以抵抗广泛的食源性病原体和家禽病原体，包括昂贵的球虫感染。
