• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Stimulation of homology-directed repair at I-SceI-induced DNA breaks during the permissive life cycle of human cytomegalovirus.在人巨细胞病毒的允许生活周期中，I-SceI 诱导的 DNA 断裂处同源定向修复的刺激。
J Virol. 2011 Jun;85(12):6049-54. doi: 10.1128/JVI.02514-10. Epub 2011 Apr 13.
2
Modulation of homology-directed repair in T98G glioblastoma cells due to interactions between wildtype p53, Rad51 and HCMV IE1-72.由于野生型 p53、Rad51 和 HCMV IE1-72 之间的相互作用，导致 T98G 神经胶质瘤细胞中同源重组修复的调节。
Viruses. 2014 Feb 26;6(3):968-85. doi: 10.3390/v6030968.
3
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection.人巨细胞病毒在裂解感染期间破坏共济失调毛细血管扩张突变蛋白（ATM）和ATM-Rad3相关激酶介导的DNA损伤反应。
J Virol. 2007 Feb;81(4):1934-50. doi: 10.1128/JVI.01670-06. Epub 2006 Dec 6.
4
An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.E2F1 介导的 DNA 损伤反应有助于人类巨细胞病毒的复制。
PLoS Pathog. 2011 May;7(5):e1001342. doi: 10.1371/journal.ppat.1001342. Epub 2011 May 12.
5
Disruption of PML-associated nuclear bodies by IE1 correlates with efficient early stages of viral gene expression and DNA replication in human cytomegalovirus infection.在人巨细胞病毒感染中，IE1对PML相关核体的破坏与病毒基因表达及DNA复制的早期高效阶段相关。
Virology. 2000 Aug 15;274(1):39-55. doi: 10.1006/viro.2000.0448.
6
Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53.染色体外质粒底物中的同源重组不会被p53抑制。
Carcinogenesis. 2001 Nov;22(11):1757-63. doi: 10.1093/carcin/22.11.1757.
7
Novel real-time monitoring system for human cytomegalovirus-infected cells in vitro that uses a green fluorescent protein-PML-expressing cell line.一种用于体外人巨细胞病毒感染细胞的新型实时监测系统，该系统使用表达绿色荧光蛋白-PML的细胞系。
Antimicrob Agents Chemother. 2006 Aug;50(8):2806-13. doi: 10.1128/AAC.01641-05.
8
The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10).人类巨细胞病毒IE2蛋白和UL112 - 113蛋白在从早幼粒细胞白血病蛋白相关核体（PODs或ND10）周边起始的病毒DNA复制区室中积累。
J Virol. 1999 Dec;73(12):10458-71. doi: 10.1128/JVI.73.12.10458-10471.1999.
9
Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection.致癌等位基因的表达会诱导对人巨细胞病毒感染的多种阻断。
J Virol. 2016 Apr 14;90(9):4346-4356. doi: 10.1128/JVI.00179-16. Print 2016 May.
10
Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter.染色质重塑因子 SPOC1 通过抑制主要早期即刻启动子发挥细胞限制因子的作用，抑制人类巨细胞病毒。
J Virol. 2018 Jun 29;92(14). doi: 10.1128/JVI.00342-18. Print 2018 Jul 15.

引用本文的文献

1
DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus.DNA 损伤反应（DDR）：细胞衰老与人类巨细胞病毒之间的联系。
Virol J. 2023 Nov 1;20(1):250. doi: 10.1186/s12985-023-02203-y.
2
Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1.人巨细胞病毒利用多种病毒蛋白来调节基底膜蛋白巢蛋白 1。
J Virol. 2022 Oct 26;96(20):e0133622. doi: 10.1128/jvi.01336-22. Epub 2022 Oct 11.
3
Human Cytomegalovirus Induces Vitamin-D Resistance In Vitro by Dysregulating the Transcriptional Repressor Snail.人巨细胞病毒通过失调转录抑制因子 Snail 诱导维生素 D 抵抗体外。
Viruses. 2022 Sep 10;14(9):2004. doi: 10.3390/v14092004.
4
Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks.人巨细胞病毒蛋白 IE1 对结构特异性内切酶 FEN1 的功能调节提示其在病毒复制叉停滞的重新起始中发挥作用。
PLoS Pathog. 2021 Mar 26;17(3):e1009460. doi: 10.1371/journal.ppat.1009460. eCollection 2021 Mar.
5
Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1.人巨细胞病毒与基底膜蛋白巢蛋白 1 的相互作用。
J Virol. 2021 Jan 13;95(3). doi: 10.1128/JVI.01506-20.
6
Wide spectrum and high frequency of genomic structural variation, including transposable elements, in large double-stranded DNA viruses.大型双链DNA病毒中基因组结构变异的广泛谱系和高频发生，包括转座元件。
Virus Evol. 2020 Jan 27;6(1):vez060. doi: 10.1093/ve/vez060. eCollection 2020 Jan.
7
Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter.染色质重塑因子 SPOC1 通过抑制主要早期即刻启动子发挥细胞限制因子的作用，抑制人类巨细胞病毒。
J Virol. 2018 Jun 29;92(14). doi: 10.1128/JVI.00342-18. Print 2018 Jul 15.
8
The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress.人巨细胞病毒感染期间p53缺失会导致UL53表达降低，破坏UL50在内核膜上的定位，从而抑制衣壳核输出。
Virology. 2016 Oct;497:262-278. doi: 10.1016/j.virol.2016.07.020. Epub 2016 Aug 4.
9
DNA repair mechanisms and human cytomegalovirus (HCMV) infection.DNA修复机制与人类巨细胞病毒（HCMV）感染
Folia Microbiol (Praha). 2015 May;60(3):199-209. doi: 10.1007/s12223-014-0359-6. Epub 2014 Nov 1.
10
Modulation of homology-directed repair in T98G glioblastoma cells due to interactions between wildtype p53, Rad51 and HCMV IE1-72.由于野生型 p53、Rad51 和 HCMV IE1-72 之间的相互作用，导致 T98G 神经胶质瘤细胞中同源重组修复的调节。
Viruses. 2014 Feb 26;6(3):968-85. doi: 10.3390/v6030968.

本文引用的文献

1
Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.单纯疱疹病毒 1 型核酸外切酶 UL12 与 DNA 双链断裂感应 MRN 复合物的物理相互作用。
J Virol. 2010 Dec;84(24):12504-14. doi: 10.1128/JVI.01506-10. Epub 2010 Oct 13.
2
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.猿猴病毒 40 大 T 抗原导致多个 DNA 损伤信号转导和修复途径失调控。
J Virol. 2010 Aug;84(16):8007-20. doi: 10.1128/JVI.00334-10. Epub 2010 Jun 2.
3
Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr virus replication compartments.在爱泼斯坦-巴尔病毒复制区室中，同源重组修复因子被招募并加载到病毒DNA基因组上。
J Virol. 2009 Jul;83(13):6641-51. doi: 10.1128/JVI.00049-09. Epub 2009 Apr 22.
4
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.猿猴病毒40大T抗原通过与Bub1结合破坏基因组完整性并激活DNA损伤反应。
J Virol. 2009 Jan;83(1):117-27. doi: 10.1128/JVI.01515-08. Epub 2008 Oct 15.
5
Repair of I-SceI induced DSB at a specific site of chromosome in human cells: influence of low-dose, low-dose-rate gamma-rays.人类细胞中染色体特定位点处 I-SceI 诱导的双链断裂修复：低剂量、低剂量率γ射线的影响
Radiat Environ Biophys. 2008 Nov;47(4):439-44. doi: 10.1007/s00411-008-0179-7. Epub 2008 Jun 21.
6
Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells.在感染猿猴病毒40的灵长类细胞中，共济失调毛细血管扩张症突变损伤信号激酶和蛋白酶体依赖性的Mre11-Rad50-Nbs1亚基的破坏
J Virol. 2008 Jun;82(11):5316-28. doi: 10.1128/JVI.02677-07. Epub 2008 Mar 19.
7
FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.FANCG促进一种新发现的包含BRCA2、FANCD2和XRCC3的蛋白质复合物的形成。
Oncogene. 2008 Jun 12;27(26):3641-52. doi: 10.1038/sj.onc.1211034. Epub 2008 Jan 21.
8
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.由范可尼贫血蛋白和乳腺癌易感基因（BRCA）蛋白组成的DNA损伤反应网络的出现。
Nat Rev Genet. 2007 Oct;8(10):735-48. doi: 10.1038/nrg2159. Epub 2007 Sep 4.
9
Human cytomegalovirus (HCMV) and hearing impairment: infection of fibroblast cells with HCMV induces chromosome breaks at 1q23.3, between loci DFNA7 and DFNA49 -- both involved in dominantly inherited, sensorineural, hearing impairment.人巨细胞病毒（HCMV）与听力障碍：用HCMV感染成纤维细胞会在1q23.3处诱导染色体断裂，该位置位于DFNA7和DFNA49基因座之间，这两个基因座都与显性遗传的感音神经性听力障碍有关。
Mutat Res. 2008 Jan 1;637(1-2):56-65. doi: 10.1016/j.mrfmmm.2007.07.009. Epub 2007 Jul 25.
10
Long-term infection and shedding of human cytomegalovirus in T98G glioblastoma cells.人巨细胞病毒在T98G胶质母细胞瘤细胞中的长期感染与释放
J Virol. 2007 Oct;81(19):10424-36. doi: 10.1128/JVI.00866-07. Epub 2007 Jul 25.

在人巨细胞病毒的允许生活周期中，I-SceI 诱导的 DNA 断裂处同源定向修复的刺激。

Stimulation of homology-directed repair at I-SceI-induced DNA breaks during the permissive life cycle of human cytomegalovirus.

机构信息

Department of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, ID 83844-3051, USA.

出版信息

J Virol. 2011 Jun;85(12):6049-54. doi: 10.1128/JVI.02514-10. Epub 2011 Apr 13.

DOI:10.1128/JVI.02514-10
PMID:21490102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3126324/
Abstract

Human cytomegalovirus (HCMV) selectively relocalizes many DNA repair proteins, thereby avoiding a potentially detrimental damage response. In the present study, we evaluated interactions between HCMV and the homology-directed repair (HDR) pathway. In permissive human foreskin fibroblasts, a fluorescence-based double-stranded break repair assay was used to determine that HCMV stimulated HDR. Repair of both stably integrated and extrachromosomal reporter substrates was observed to increase. HDR was also stimulated through individual expression of the viral immediate-early protein IE1-72, mimicking full virus infection. These experiments further demonstrate HCMV's role in modulating critical cellular processes during a permissive infection.

摘要

人巨细胞病毒（HCMV）选择性地重新定位许多 DNA 修复蛋白，从而避免潜在的有害损伤反应。在本研究中，我们评估了 HCMV 与同源定向修复（HDR）途径之间的相互作用。在允许的人包皮成纤维细胞中，使用基于荧光的双链断裂修复测定法来确定 HCMV 刺激 HDR。观察到稳定整合和染色体外报告子底物的修复均增加。通过病毒立即早期蛋白 IE1-72 的单独表达也刺激了 HDR，模拟了完整病毒感染。这些实验进一步证明了 HCMV 在调节允许感染期间关键细胞过程中的作用。