Bonte Frederick J, Hynan Linda, Harris Thomas S, White Charles L
Department of Radiology, Nuclear Medicine Center, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Int J Mol Imaging. 2011;2011:409101. doi: 10.1155/2011/409101. Epub 2010 Dec 1.
The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias. Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Images were further processed using Statistical Parametric Mapping. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 73 subjects were compared with a neuropathologic study of the brain at autopsy. Data were analyzed for sensitivity, specificity, positive and negative predictive values and accuracy. These results are compared with several other studies performed with Tc-99m HMPAO SPECT with histopathologic correlation. This procedure is widely available and relatively inexpensive and may be of value in patients with dementias and problematic diagnoses. Further, a degree of differential diagnosis between Alzheimer's and Frontotemporal diseases may be effected. The study was approved by our Institutional Review Board.
本研究的目的是确定锝-99m六甲基丙二胺肟单光子发射计算机断层扫描（Tc-99m HMPAO SPECT）在痴呆诊断中的价值。使用Tc-99m HMPAO和三探头扫描仪生成5组脑部断层图像。图像进一步采用统计参数映射法进行处理。诊断由对临床诊断不知情的医生做出。将73名受试者的结果与尸检时的脑部神经病理学研究进行比较。分析数据的敏感性、特异性、阳性和阴性预测值以及准确性。将这些结果与其他几项采用Tc-99m HMPAO SPECT并与组织病理学相关的研究进行比较。该检查方法广泛可用且相对便宜，可能对患有痴呆症且诊断有问题的患者有价值。此外，可能有助于对阿尔茨海默病和额颞叶疾病进行一定程度的鉴别诊断。本研究已获得我们机构审查委员会的批准。
